A time differentiated dietary intervention effect on the biomarkers of exposure to pyrethroids and neonicotinoids pesticides

Tailoring medical models to the right person or risk subgroups delivered at the right time is important in personalized medicine/prevention initiatives. The CIRCA-CHEM randomized 2x2 crossover pilot trial investigated whether the consumption of fruits/vegetables within a time-restricted daily window...

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Bibliographic Details
Published in:iScience 2023-02, Vol.26 (2), p.105847-105847, Article 105847
Main Authors: Ioannou, Elina, Oikonomou, Stavros, Efthymiou, Nikolaos, Constantinou, Andria, Delplancke, Thibaut, Charisiadis, Pantelis, Makris, Konstantinos C.
Format: Article
Language:English
Subjects:
Exposure assessment
Food science
Toxicology
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Summary:Tailoring medical models to the right person or risk subgroups delivered at the right time is important in personalized medicine/prevention initiatives. The CIRCA-CHEM randomized 2x2 crossover pilot trial investigated whether the consumption of fruits/vegetables within a time-restricted daily window would affect urinary biomarkers of exposure to neonicotinoids (6-chloronicotinic acid, 6-CN) and pyrethroids (3-phenoxybenzoic acid, 3-PBA) pesticides, a biomarker of oxidative damage (4-hydroxynonenal, 4-HNE) and the associated urinary NMR metabolome. A statistically significant difference (p < 0.001) in both creatinine-adjusted 6-CN and 3-PBA levels was observed between the two-time dietary intervention windows (morning vs. evening). In the evening intervention period, pesticides biomarker levels were higher compared to the baseline, whereas in the morning period, pesticide levels remained unchanged. Positive associations were observed between pesticides and 4-HNE suggesting a diurnal chrono-window of pesticide toxicity. The discovery of a chronotoxicity window associated with chrono-disrupted metabolism of food contaminants may find use in personalized medicine initiatives. [Display omitted] •Time of day that food is consumed affects the body burden of pesticides•Higher urinary metabolized pesticides when foods are consumed at night vs morning•Association of metabolized pesticides with a marker of oxidative damage•Evidence of chronodisrupted metabolism of ubiquitous pesticides in common foods Toxicology; Exposure assessment; Food science
ISSN:2589-0042
2589-0042
DOI:10.1016/j.isci.2022.105847