Psychometric properties of the PROMIS Preference score (PROPr) in patients with rheumatological and psychosomatic conditions

• Published in: BMC rheumatology 2022-03, Vol.6 (1), p.15-15, Article 15
• Main Authors: Klapproth, C P, Fischer, F, Merbach, M, Rose, M, Obbarius, A
• Format: Article
• Language: English
• Subjects: Health status; Outcome measures; Pain; Patient reported outcomes; QALY; Quality of life
• ISSN: 2520-1026; 2520-1026
• DOI: 10.1186/s41927-022-00245-3

The PROMIS Preference score (PROPr) is a new generic preference-based health-related quality of life (HRQoL) score that can be used as a health state utility (HSU) score for quality-adjusted life years (QALYs) in cost-utility analyses (CUAs). It is the first HSU score based on item response theory (IRT) and has demonstrated favorable psychometric properties in first analyses. The PROPr combines the seven PROMIS domains: cognition, depression, fatigue, pain, physical function, sleep disturbance, and ability to participate in social roles and activities. It was developed based on preferences of the US general population. The aim of this study was to validate the PROPr in a German inpatient sample and to compare it to the EQ-5D. We collected PROPr and EQ-5D-5L data from 141 patients undergoing inpatient treatment in the rheumatology and psychosomatic departments. We evaluated the criterion and convergent validity, and ceiling and floor effects of the PROPr and compared those characteristics to those of the EQ-5D. The mean PROPr (0.26, 95% CI: 0.23; 0.29) and the mean EQ-5D (0.44, 95% CI: 0.38; 0.51) scores differed significantly (d = 0.18, p