Disulfiram Induced Reversible Hypertension: A Prospective Case Study and Brief Review

Disulfiram (DSF) is one of the recommended aids in the management of alcohol dependence. Hypertension may be a clinically significant, dose-dependent, and usually reversible adverse event of DSF therapy. We report 6 month prospective study of normotensive case of comorbid alcohol and tobacco depende...

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Bibliographic Details
Published in:Indian journal of psychological medicine 2013-04, Vol.35 (2), p.217-219
Main Authors: Kulkarni, Ranganath R., Bairy, Bhavya K.
Format: Article
Language:English
Subjects:
Adverse event
alcohol dependence
Alcoholism
Blood pressure
Case Report
Case studies
Comorbidity
Compliance
Dehydrogenases
Disulfiram
Dopamine
Drug dosages
Enzymes
Ethanol
Headaches
Hypertension
Lifestyles
Metabolites
Tobacco
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Summary:Disulfiram (DSF) is one of the recommended aids in the management of alcohol dependence. Hypertension may be a clinically significant, dose-dependent, and usually reversible adverse event of DSF therapy. We report 6 month prospective study of normotensive case of comorbid alcohol and tobacco dependence that developed reversible stage-II hypertension within 2-4 weeks of DSF therapy. We suggest that regular monitoring of blood pressure at least fortnightly for 1 st 3 months, followed by monthly for next 3 months, and later once in 3 months, may possibly detect "silent" adverse event of DSF - hypertension.
ISSN:0253-7176
0975-1564
DOI:10.4103/0253-7176.116263