A randomized, Double-blind Clinical Trial of the Three-month Effect of Garlic Administration on Cardiac Outcomes in Patients with Heart Failure

Keywords: Heart Failure, Garlic, Randomized Controlled Trial, Quality of Life Introduction Heart failure (HF) is a clinical syndrome caused by any functional or structural defect in either blood ejection or ventricular filling.1 Worldwide, approximately 26 million individuals are affected by HF.2 Th...

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Published in:ARYA atherosclerosis 2022-12, Vol.18 (December), p.1-10
Main Authors: Azish, Sima, Garakyaraghi, Mohammad, Vakhshoori, Mehrbod, Heidarpour, Maryam, Behjati, Mohaddeseh, Heshmat-Ghahdarijani, Kiyan, Sarrafzadegan, Nizal, Omoomi, Sepehr, Fakhrolmobasheri, Mohammad, Shafie, Davood
Format: Article
Language:English
Subjects:
Blood pressure
Cardiac function
Chronic obstructive pulmonary disease
Clinical trials
Double-blind studies
Drug dosages
Ejection fraction
Garlic
Heart failure
Laboratories
Population
Quality of life
Questionnaires
randomized controlled trial
Thyroid gland
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Summary:Keywords: Heart Failure, Garlic, Randomized Controlled Trial, Quality of Life Introduction Heart failure (HF) is a clinical syndrome caused by any functional or structural defect in either blood ejection or ventricular filling.1 Worldwide, approximately 26 million individuals are affected by HF.2 This global concern's prevalence has been reported to rise with age. Allicin is an active garlic metabolite that has been shown to lower cholesterol and blood pressure while inhibiting platelet aggregation.12 Moreover, this plant has been linked to antioxidant properties and the healing of endothelial injuries.13 Hara et al. discovered that rats who received garlic extract had lower left ventricular (LV) fibrosis and improved LV diastolic dysfunction.14 However, more clinical research is needed to prove garlic's possible effect on cardiovascular outcomes. [...]everyone who took part signed a written consent form. A fasting blood sample was drawn to measure the serum levels of indices, including a lipid profile, renal function, coagulation factors, hemoglobin (Hb) (g/dl), platelets (109/1), fasting blood sugar (FBS) (mg/dl), and thyroid-stimulating hormone (TSH) (ulU/ml). [...]echocardiography was used to assess the following parameters: end-diastolic diameter (10) (mm), ventricular septal thickness (VST) (mm), and LVEF (%).
ISSN:1735-3955
2251-6638
DOI:10.48305/arya.2022.11840.2515