Successful infusional 5-fluorouracil administration in a patient with vasospastic angina

A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has...

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Bibliographic Details
Published in:American heart journal plus 2022-05, Vol.17, p.100147, Article 100147
Main Authors: Tai, Shannon, Mohananey, Divyanshu, Griffiths, Claire, Johnson, Bradley, Garg, Jalaj, Ridolfi, Timothy J., Lohr, Nicole L., Chakrabarti, Sakti, Brown, Sherry-Ann
Format: Article
Language:English
Subjects:
5-Fluorouracil
Cardio-oncology
Coronary vasospasm
Variant angina
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Summary:A 48-year-old female with metastatic colon adenocarcinoma and history of pre-existing coronary vasospasm with ventricular tachycardia (VT) successfully tolerated de novo 5-fluorouracil (5-FU) chemotherapy infusions with prophylactic administration and optimization of anti-spasm medications. 5-FU has been reported to produce severe cardiotoxic side effects, including coronary vasospasm, ventricular arrhythmias, and sudden cardiac death, and is not typically reported in individuals with pre-existing coronary vasospasm.
ISSN:2666-6022
2666-6022
DOI:10.1016/j.ahjo.2022.100147