The role for nitric oxide on the effects of hydroalcoholic extract of Achillea wilhelmsii on seizure

Objective : Nitric oxide (NO) plays an important role both as a consequence and as a cause of epileptic seizures. Regarding the central nervous system depressant effects of Achillea wilhelmsii (A. wilhelmsii), as well the effects of the plant on NO, this study was aimed to elucidate the possible rol...

Full description

Saved in:
Bibliographic Details
Published in:Avicenna journal of phytomedicine 2014-07, Vol.4 (4), p.251-259
Main Authors: Hosseini, Mahmoud, Harandizadeh, Fatemeh, Niazmand, Saeed, Soukhtanloo, Mohammad, Faizpour, Azadeh, Ghasemabady, Marzieh
Format: Article
Language:English
Subjects:
Achillea wilhelmsii
Hippocampus
Nitric oxide
Original Research Paper
Pentylenetetrazole
Rat
Seizures
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective : Nitric oxide (NO) plays an important role both as a consequence and as a cause of epileptic seizures. Regarding the central nervous system depressant effects of Achillea wilhelmsii (A. wilhelmsii), as well the effects of the plant on NO, this study was aimed to elucidate the possible role for nitric oxide on the effects of hydroalcoholic extract of A. wilhelmsii on pentylenetetrazole (PTZ)-induced seizures. Fifty-six male Wistar rats were divided into 7 groups (n=8 in each group) and treated with (1) normal saline, (2) normal saline before pentylenetetrazole (PTZ, 90 mg/kg), (3-7) A. wilhelmsii extract (100, 200, 400, 800, and 1200 mg/kg) before PTZ. Latency to first minimal colonic seizure (MCS) and the first generalized tonic-clonic seizures (GTCS) as well as the mortality rate were recorded. The brain tissues were then removed for biochemical measurements. Fisher's exact probability test as well as analysis of variance (ANOVA), followed by Tukey's test were used for statistical evaluation. Treatment with 100- 1200 mg/kg of the extract did not affect MCS latencies. 400 mg/kg of the extract prolonged GTCS latency (p
ISSN:2228-7930
2228-7949