Exploring the brain epitranscriptome: perspectives from the NSAS summit

Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neur...

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Published in:Frontiers in neuroscience 2023-10, Vol.17, p.1291446
Main Authors: Lee, Sung-Min, Koo, Bonsang, Carré, Clément, Fischer, André, He, Chuan, Kumar, Ajeet, Liu, Kathy, Meyer, Kate D, Ming, Guo-Li, Peng, Junmin, Roignant, Jean-Yves, Storkebaum, Erik, Sun, Shuying, De Pietri Tonelli, Davide, Wang, Yinsheng, Weng, Yi-Lan, Pulvirenti, Luigi, Shi, Yanhong, Yoon, Ki-Jun, Song, Hongjun
Format: Article
Language:English
Subjects:
Amyotrophic lateral sclerosis
Brain
Brain tumors
Cell cycle
Dementia
Disease
epitranscriptome
Glioblastoma
Intellectual disabilities
Life Sciences
Localization
Mental disorders
Microencephaly
Nervous system
Neurodegeneration
Neurodevelopment
neuroepitranscriptomics
Neurogenesis
Neuroplasticity
Neuroscience
Neurosciences
Proteins
Regeneration
Ribonucleic acid
RNA
RNA modifications
Seizures
Stem cells
Systems development
Transfer RNA
Tumorigenesis
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Summary:Increasing evidence reinforces the essential function of RNA modifications in development and diseases, especially in the nervous system. RNA modifications impact various processes in the brain, including neurodevelopment, neurogenesis, neuroplasticity, learning and memory, neural regeneration, neurodegeneration, and brain tumorigenesis, leading to the emergence of a new field termed neuroepitranscriptomics. Deficiency in machineries modulating RNA modifications has been implicated in a range of brain disorders from microcephaly, intellectual disability, seizures, and psychiatric disorders to brain cancers such as glioblastoma. The inaugural NSAS Challenge Workshop on Brain Epitranscriptomics hosted in Crans-Montana, Switzerland in 2023 assembled a group of experts from the field, to discuss the current state of the field and provide novel translational perspectives. A summary of the discussions at the workshop is presented here to simulate broader engagement from the general neuroscience field.
ISSN:1662-4548
1662-453X
1662-453X
DOI:10.3389/fnins.2023.1291446