Chlorogenic acid enhances intestinal barrier by decreasing MLCK expression and promoting dynamic distribution of tight junction proteins in colitic rats

•CGA inhibits the activation of MLC kinase to prevent MLC phosphorylation.•CGA reduces the depolymerisation of F-actin to make the stabilisation of tight junction.•CGA regulates dynamic distribution of occludin and claudin-1. The aim of the present study was to evaluate the effect of chlorogenic aci...

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Bibliographic Details
Published in:Journal of functional foods 2016-10, Vol.26, p.698-708
Main Authors: Ruan, Zheng, Mi, Shumei, Zhou, Lili, Zhou, Yan, Li, Jing, Liu, Wenhui, Deng, Zeyuan, Yin, Yulong
Format: Article
Language:English
Subjects:
Chlorogenic acid
Colitis
Dynamic distribution
Intestinal barrier
Myosin light chain kinase
Tight junction
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Summary:•CGA inhibits the activation of MLC kinase to prevent MLC phosphorylation.•CGA reduces the depolymerisation of F-actin to make the stabilisation of tight junction.•CGA regulates dynamic distribution of occludin and claudin-1. The aim of the present study was to evaluate the effect of chlorogenic acid (CGA) on the mucosal barrier function and tight junction proteins in colitic rats. CGA (60 mg/kg body weight) significantly decreased the ratio of lactulose to mannitol (L/M) (P 
ISSN:1756-4646
2214-9414
DOI:10.1016/j.jff.2016.08.038