Association between tooth loss and depression mediated by lifestyle and Inflammation- a cross-sectional investigation

• Published in: BMC public health 2024-09, Vol.24 (1), p.2627-10, Article 2627
• Main Authors: Hao, Yaqi, Yuan, Zhimin, Zhu, Yingze, Li, Shaoru, Gou, Jingning, Dong, Shaojie, Niu, Lin
• Format: Article
• Language: English
• Subjects: Adult; Aged; Alcohol use; Chronic illnesses; Complications and side effects; Cross-Sectional Studies; Depression; Depression - epidemiology; Depression, Mental; Disease; Education; Ethnicity; Exercise; Family income; Female; Females; Gender; Health behavior; Healthy lifestyle; HEI-2015 score; Humans; Hypertension; Inflammation; Insulin resistance; Investigations; Life Style; Lifestyles; Male; Mental depression; Mental disorders; Middle Aged; NHANES; Nutrition research; Nutrition Surveys; Oral hygiene; Psychological aspects; Psychological factors; Psychological stress; Public health; Regression analysis; Regression models; Risk factors; Secondary schools; Systemic immune-inflammation index; Teeth; Tooth loss; Tooth Loss - epidemiology; Tooth Loss - psychology; Variance analysis
• ISSN: 1471-2458; 1471-2458
• DOI: 10.1186/s12889-024-20065-z

Depression and tooth loss are associated with the occurrence of systemic disease or the progression of multi-factorial disease, and both are considered important public health issues by World Health Organization (WHO). Previous research just suggested that tooth loss can generate psychological stress, low self-esteem, anxiety and other emotional disturbances. However, the precise correlation and underlying mechanisms between depression and tooth loss remains poorly understood. ​Consequently, we aim to explore the association between depression and tooth loss through a cross-sectional study, as well as investigate potential pathways of influence. We analyzed data from the National Health and Nutrition Examination Survey (NHANES). Logistic regression models were employed to examine the relationship between depression and tooth loss, as well as the associations among healthy lifestyle, systemic immune-inflammation index (SII), depression and tooth loss. Through the mediating effect analysis by bootstrapping analysis, we evaluated the mediating effects of healthy lifestyle and SII between depression and tooth loss. Depressed patients were more likely to be toothless, and at the same time showed a tendency to have more missing teeth, with odds ratio (OR) = 1.305 (1.098, 1.551), p = 0.003 for 1-7 missing teeth, OR = 1.557 (1.166, 2.079), p = 0.003 for 8-14 missing teeth, and OR = 1.960 (1.476, 2.603), p