Larvicidal properties of essential oils of three Artemisia species against the chemically insecticide-resistant Nile fever vector Culex pipiens (L.) (Diptera: Culicidae): In vitro and in silico studies

The objective of this study is to determine the larvicidal activity of essential oils (EOs) extracted from three plants of the genus against the mosquito ( ) using and studies. A total number of 20 third- and fourth-instar larvae were exposed to various concentrations of the three plants. The LC and...

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Bibliographic Details
Published in:Open Chemistry 2024-10, Vol.22 (1), p.592-9
Main Authors: Chebbac, Khalid, Abchir, Oussama, Chalkha, Mohammed, El Moussaoui, Abdelfattah, El kasmi-alaoui, Mohammed, Lafraxo, Soufyane, Chtita, Samir, Alanazi, Mohammed M., Alanazi, Ashwag S., Hefnawy, Mohamed, Zouirech, Otmane, Ouaritini, Zineb Benziane, Guemmouh, Raja
Format: Article
Language:English
Subjects:
artemisia species
bioassay larvicide
culex pipiens
endemic
essential oil
in silico
lethal concentration
species
vector
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Summary:The objective of this study is to determine the larvicidal activity of essential oils (EOs) extracted from three plants of the genus against the mosquito ( ) using and studies. A total number of 20 third- and fourth-instar larvae were exposed to various concentrations of the three plants. The LC and LC values of the tested Artemisia EOs were determined using Probit analysis. In addition, the sensitivity of to these EOs was determined and compared against a standard insecticide, temephos, under laboratory conditions. Furthermore, assessments were carried out on the major constituents to help understand and explain the acquired results. Gas chromatography analysis identified the major compounds as -limonene and β-pinene for , camphor and borneol for , and artemisia ketone and caryophyllene for . oil showed the highest efficacy against larvae, followed by oil with average larvicidal activity. In contrast, EO, composed of a high percentage of monoterpenes, was the least active. Docking simulation indicated that several studied ligands had promising binding scores within the receptor’s binding site compared to the reference insecticide temephos. The obtained results allow us to conclude that , a species endemic to Morocco, is an excellent means of controlling
ISSN:2391-5420
2391-5420
DOI:10.1515/chem-2024-0108