Functional targeted therapy for glioma based on platelet membrane-coated nanogels

Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects the treatment of glioma. Herein, we develo...

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Bibliographic Details
Published in:Cancer nanotechnology 2023-12, Vol.14 (1), p.12-17, Article 12
Main Authors: Li, Qin, Shen, Jinglan, Wu, Lingling, Lei, Siyun, Yang, Yimin, Xu, Weide, Hao, Ke, Zhang, Yi, Kong, Fei, Yang, Wei, Wang, Yaling, Peng, Lina, Li, Kaiqiang, Wang, Zhen
Format: Article
Language:English
Subjects:
Biochemistry
Biomedical Engineering and Bioengineering
Biomimetic drug delivery system
Biomimetics
Blood platelets
Blood-brain barrier
Cancer Research
Cancer therapies
Chemistry and Materials Science
Doxorubicin
Drug delivery systems
Drugs
Glioma
Hospitals
Immune system
Laboratory animals
Materials Science
Medical research
Medicine
Membranes
Mimicry
Nanogel
Nanomaterials
Nanoparticles
Nanotechnology
Peptides
Platelet membrane
Platelets
Tumors
Vasculogenic mimicry
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Summary:Glioma treatment remains a challenge owing to unsatisfactory targeted chemotherapy, where the blood–brain barrier (BBB) hinders the efficient uptake of therapeutics into the brain. Vasculogenic mimicry (VM) formed by invasive glioma cells negatively affects the treatment of glioma. Herein, we developed a targeted biomimetic drug delivery system comprising a doxorubicin-loaded platelet membrane-coated nanogel (DOX@PNGs). The nanogels provide great redox/pH dual responsiveness, while the platelet membrane (PLTM) promotes stability and circulation time. In vitro cellular uptake and in vivo imaging experiments demonstrated that the DOX@PNGs delivery system could penetrate the BBB, target gliomas, and destruct VM. DOX@PNGs increased drug penetration and prolonged mouse survival time during the treatment of orthotopic gliomas. These results indicate this biomimetic drug delivery system to be promising for glioma treatment and may be clinically translated in the future.
ISSN:1868-6958
1868-6966
DOI:10.1186/s12645-023-00167-w