Analogs of the carotane antibiotic fulvoferruginin from submerged cultures of a Thai Marasmius sp

A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin ( 1 ), fulvoferruginins B–F ( 2 – 6 ). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spec...

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Bibliographic Details
Published in:Beilstein journal of organic chemistry 2021-06, Vol.17 (1), p.1385-1391
Main Authors: Sandargo, Birthe, Kaysan, Leon, Teponno, Rémy B, Richter, Christian, Thongbai, Benjarong, Surup, Frank, Stadler, Marc
Format: Article
Language:English
Subjects:
Antibiotics
basidiomycota
Biological activity
carotane
Chemistry
Cytotoxicity
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fulvoferruginin
Marasmius
Metabolites
NMR
Nuclear magnetic resonance
sesquiterpenoid
Sesquiterpenoids
Spectroscopy
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Summary:A recent find of a Marasmius species in Northern Thailand led to the isolation of five unprecedented derivatives of the carotane antibiotic fulvoferruginin ( 1 ), fulvoferruginins B–F ( 2 – 6 ). The structures of these sesquiterpenoids were elucidated using HRESIMS, 1D and 2D NMR, as well as CD spectroscopy. Assessing the bioactivity, fulvoferruginin emerged as a potent cytotoxic agent of potential pharmaceutical interest.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.17.97