Identification of Breast Cancer-Associated Lipids in Scalp Hair

A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date...

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Bibliographic Details
Published in:Breast Cancer: Basic and Clinical Research 2012-01, Vol.2012 (2012), p.113-123
Main Authors: Mistry, Dharmica A.H., Haklani, Joseph, French, Peter W.
Format: Article
Language:English
Subjects:
Animal models in research
Biological markers
Breast cancer
Diagnosis
Genetic aspects
Health aspects
Lipids
Original Research
Physiological aspects
Prognosis
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Summary:A correlation between the presence of breast cancer and a change in the synchrotron-generated X-ray diffraction (XRD) pattern of hair has been reported in several publications by different groups, and on average XRD-based assays detect around 75% of breast cancer patients in blinded studies. To date, the molecular mechanisms leading to this alteration are largely unknown. We have determined that the alteration is likely to be due to the presence of one or more breast cancer-associated phospholipids. Further characterization of these lipids could be used to develop a novel, sensitive and specific screening test for breast cancer, based on hair initially, and potentially extendable to other biological samples.
ISSN:1178-2234
1178-2234
DOI:10.4137/BCBCR.S9607