A new parameter to increase the predictive value of multiparametric prostate magnetic resonance imaging for clinically significant prostate cancer in targeted biopsies: lesion density

• Published in: Prostate international 2024-09, Vol.12 (3), p.145-150
• Main Authors: Şahin, Bahadır, Çelik, Serdar, Sözen, Sinan, Türkeri, Levent, Aslan, Güven, Yazıcı, Sertaç, Çetin, Serhat
• Format: Article
• Language: English
• Subjects: Multiparametric magnetic resonance imaging; Prostate-specific antigen; Prostatic neoplasms
• ISSN: 2287-8882
• DOI: 10.1016/j.prnil.2024.06.001

To investigate the predictive value of lesion length in multiparametric prostate magnetic resonance imaging with respect to prostate volume for clinically significant prostate cancer diagnosis in targeted biopsies. The data of biopsy-naïve patients in the Turkish Urooncology Association Prostate Cancer Database who underwent targeted prostate biopsies were included in this study. Lesion density is calculated as the ratio of lesion length (mm) in MR to prostate volume (cc). The biopsy results were divided into either clinically significant or insignificant cancer and benign groups. The difference in parameters between groups is evaluated by multivariable analysis to determine independent risk factors for clinically significant prostate cancer diagnosis. A total of 590 lesion biopsies were included in the study. In univariable analysis, prostate-specific antigen (PSA), PSA density, number of cores taken, lesion length, lesion density, patient age, and digital rectal examination findings were found to be different at a statistically significant level between groups (P values, respectively: 0.001,