Meta-Analysis of Randomized Clinical Trials Evaluating Effectiveness of a Multivitamin Supplementation against Oxidative Stress in Healthy Subjects

A meta-analysis has been widely applied to draw general conclusions using a set of studies with similar purposes and designs. This study aimed to perform a meta-analysis of six randomized placebo-controlled trials, independently conducted for the relationship between a plant-based multivitamin/miner...

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Bibliographic Details
Published in:Nutrients 2022-03, Vol.14 (6), p.1170
Main Authors: Lee, Seoyoung, Huh, Iksoo, Kang, Seunghee, Nam, Yea-Eun, Cho, Youngseo, Kamruzzaman, Md, Hong, Jina, Kwon, Oran, Park, Taesung
Format: Article
Language:English
Subjects:
Ascorbic acid
Association analysis
Carotene
Chronic illnesses
Clinical trials
Dietary minerals
Dietary Supplements
exogenous oxidant scavenger
Folic acid
Free radicals
Fruits
Healthy Volunteers
Humans
Inequality
Low density lipoprotein
Meta-analysis
multivitamin supplementation
Nutrients
Oxidants
oxidative damage
Oxidative Stress
Oxidizing agents
Phytochemicals
Randomized Controlled Trials as Topic
Sample size
Scavenging
Subgroups
Vitamin B12
Vitamin B6
Vitamins
Vitamins - pharmacology
Vitamins - therapeutic use
β-Carotene
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Summary:A meta-analysis has been widely applied to draw general conclusions using a set of studies with similar purposes and designs. This study aimed to perform a meta-analysis of six randomized placebo-controlled trials, independently conducted for the relationship between a plant-based multivitamin/mineral supplementation (PMS) and oxidative stress for 6 to 8 weeks, to provide overall estimates of those effects. In detail, linear mixed model analysis was first conducted on each study to obtain individual estimates; then, two types of meta-analysis were applied to combine the individual estimates from all available studies (overall meta-analysis) and region-specific studies (subgroup meta-analysis). In the meta-analysis, we selected 19 biomarker variables that overlapped in at least two studies and found 6 variables significant in at least one meta-analysis. The overall estimates of beta coefficients were 0.17 for vitamin C, 0.80 for vitamin B , 0.46 for vitamin B , 0.81 for folate, 0.36 for -carotene, and -0.17 for oxidized LDL (ox-LDL). Subsequent association analysis revealed significant negative correlations between plasma free radical scavenging nutrients and plasma ox-LDL levels, indicating a general benefit of PMS in alleviating oxidative stress by providing exogenous oxidant scavengers.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14061170