The Rapid Antigen Detection Test for SARS-CoV-2 Underestimates the Identification of COVID-19 Positive Cases and Compromises the Diagnosis of the SARS-CoV-2 (K417N/T, E484K, and N501Y) Variants

Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies a...

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Published in:Frontiers in public health 2022-01, Vol.9, p.780801-780801
Main Authors: Barrera-Avalos, Carlos, Luraschi, Roberto, Vallejos-Vidal, Eva, Mella-Torres, Andrea, Hernández, Felipe, Figueroa, Maximiliano, Rioseco, Claudia, Valdés, Daniel, Imarai, Mónica, Acuña-Castillo, Claudio, Reyes-López, Felipe E, Sandino, Ana María
Format: Article
Language:English
Subjects:
COVID-19
COVID-19 diagnosis
COVID-19 false negative rapid test for COVID-19 diagnosis
COVID-19 Testing
Humans
pandemic control strategies
Pandemics
Public Health
rapid antigen test
SARS-CoV-2
SARS-CoV-2 detection
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Summary:Timely detection of severe acute respiratory syndrome due to coronavirus 2 (SARS-CoV-2) by reverse transcription quantitative polymerase chain reaction (RT-qPCR) has been the gold- strategy for identifying positive cases during the current pandemic. However, faster and less expensive methodologies are also applied for the massive diagnosis of COVID-19. In this way, the rapid antigen test (RAT) is widely used. However, it is necessary to evaluate its detection efficiency considering the current pandemic context with the circulation of new viral variants. In this study, we evaluated the sensitivity and specificity of RAT (SD BIOSENSOR, South Korea), widely used for testing and SARS-CoV-2 diagnosis in Santiago of Chile. The RAT showed a 90% (amplification range of 20 ≤ Cq
ISSN:2296-2565
2296-2565
DOI:10.3389/fpubh.2021.780801