Novel Opportunity to Reverse Antibiotic Resistance: To Explore Traditional Chinese Medicine With Potential Activity Against Antibiotics-Resistance Bacteria

Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditio...

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Bibliographic Details
Published in:Frontiers in microbiology 2020-12, Vol.11, p.610070-610070
Main Authors: Su, Ting, Qiu, Ye, Hua, Xuesi, Ye, Bi, Luo, Haoming, Liu, Da, Qu, Peng, Qiu, Zhidong
Format: Article
Language:English
Subjects:
active ingredients
antibiotic-resistant bacteria
Microbiology
multi-drug resistance
reversion mechanism
traditional Chinese medicine
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Summary:Antibiotic resistance is becoming significantly prominent and urgent in clinical practice with the increasing and wide application of antibacterial drugs. However, developing and synthesizing new antimicrobial drugs is costly and time-consuming. Recently, researchers shifted their sights to traditional Chinese medicine (TCM). Here, we summarized the inhibitory mechanism of TCM herbs and their active ingredients on bacteria, discussed the regulatory mechanism of TCM on antibiotic-resistant bacteria, and revealed preclinical results of TCM herbs and their active components against antibiotic-resistant bacteria in mouse models. Those data suggest that TCM herbs and their effective constituents exhibit potential blockage ability on antibiotic-resistant bacteria, providing novel therapeutic ideas for reversing antibiotic resistance.
ISSN:1664-302X
1664-302X
DOI:10.3389/fmicb.2020.610070