Bare Metal Stents on Resveratrol-Coated Balloons in Porcine Coronary and Peripheral Arteries

• Published in: International journal of molecular sciences 2021-12, Vol.22 (23), p.13099
• Main Authors: Kamann, Stefanie, Haase, Tobias, Stolzenburg, Nicola, Löchel, Melanie, Peters-Berg, Daniel, Schütt, Denise, Schnorr, Jörg
• Format: Article
• Language: English
• Subjects: Angioplasty; Angioplasty, Balloon - adverse effects; Animal models; Animals; Antioxidants; Balloon catheters; Bioavailability; Catheters; Coatings; Coronary artery; Coronary vessels; Coronary Vessels - drug effects; Disease Models, Animal; Drug dosages; drug-coated balloon catheter; Drug-Eluting Stents - adverse effects; Equipment Design; Feasibility Studies; Fibrin; Fibrin - metabolism; Healing; Implantation; Implants; Inflammation; Medical equipment; Neointima - prevention & control; neovascularization; Occlusion; Paclitaxel; Pharmacokinetics; restenosis; Resveratrol; Resveratrol - administration & dosage; Resveratrol - pharmacokinetics; stent implantation; Stents; Surgical implants; Swine; Thickening; Tumor necrosis factor-TNF; Vasa Vasorum - drug effects; vascular healing; Veins & arteries; Wound Healing - drug effects
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms222313099

Balloon angioplasty and stent implantation are standard techniques to reopen stenotic vessels. Often, balloons or stents coated with cytostatic drugs are used to prevent re-occlusion of the arteries. Resveratrol, which is known for its numerous beneficial effects on cardiovascular health, is used as an antioxidant additive on paclitaxel-coated balloon catheters. What is still unclear is whether resveratrol-only balloon coating in combination with a bare metal stent (BMS) also has positive effects on vascular healing. Here, we analyzed neointimal thickening, fibrin deposition, inflammation, vasa vasorum density, and reendothelialization after implantation of BMS via a resveratrol coated balloon approach in a porcine model. In general, resveratrol treatment did not result in significantly altered responses compared to the control group in peripheral arteries. In coronary arteries, an increase in vasa vasorum density became evident three days after resveratrol treatment compared to the control group and abolished up to day 7. Significant effects of the resveratrol treatment on the fibrin score or intima-media area were transient and restricted to either peripheral or coronary arteries. In conclusion, local single-dose resveratrol treatment via a resveratrol-only coated balloon and BMS approach did not lead to adverse systemic or local effects, but also no significant beneficial effects on vascular healing were detected in the current study.