An inverse association of weight and the occurrence of asymptomatic gallbladder stone disease in hypercholesterolemia patients: a case-control study

• Published in: Lipids in health and disease 2020-10, Vol.19 (1), p.1-228, Article 228
• Main Authors: Sheng, Binwu, Zhao, Qingbin, Ma, Mao, Zhang, Jianqin
• Format: Article
• Language: English
• Subjects: Analysis; Bile; Biological products; Blood lipids; Blood pressure; Blood sugar; Body mass index; Body weight loss; Calculi; Cancer; Cholesterol; Committees; Diabetes; Diet; Epidemiology; Fasting; Fatty liver; Gallbladder; Gallbladder cancer; Gallbladder stone disease; Gallstones; Gastrointestinal surgery; Glucose; High density lipoprotein; Hypercholesterolemia; Hyperlipidemia; Hypertension; Lifestyles; Lipids; Liver; Liver cancer; Liver diseases; Low density lipoprotein; Medical research; Medicine, Experimental; Metabolic disorders; Morbidity; Nonalcoholic fatty liver disease; Nutrition research; Obesity; Overweight; Population; Questionnaires; Regression analysis; Risk factors; Serum lipids; Ultrasonic imaging; Weight control; Westernization
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-020-01402-8

Background Despite the fact that the majority of gallstones formed in the gallbladder are mainly composed of cholesterol, as they are formed from cholesterol-supersaturated bile, and hypercholesterolemia is a common metabolic disorder, which is closely related to cardiac, hepatic, renal and other oxidative damage inflammation and necrosis, there is still no consensus regarding the contribution of blood serum lipids in the pathogenesis of gallbladder stone disease (GSD). This study aimed to investigate the relationship between hypercholesterolemia and the risk of new-onset asymptomatic GSD, and to determine the prevalence of factors associated with new-onset asymptomatic GSD in patients with hypercholesterolemia. Methods In this study, 927 Chinese patients with new-onset asymptomatic gallstone disease and 845 healthy controls were enrolled starting from August 2012. Patients were matched for age, gender, race, occupation, systolic blood pressure, diastolic blood pressure, and fasting blood glucose levels (FBG). Body mass index (BMI), nonalcoholic fatty liver disease (NAFLD) and serum lipids indexes were compared and the relationships between BMI, blood lipid and gallbladder stone hazards were examined by logistic multivariate regression models. Results The result showed a significantly higher morbidity with GSD in hypercholesterolemia than non-hypercholesterolemia patients (Χ2 = 17.211, P