Multiple sebaceous tumors in a 58‐year‐old man with colorectal cancer

The Muir‐Torre Syndrome is a rare genodermatosis, defined by the occurrence of sebaceous neoplasia and internal malignancies and caused by mutations in the mismatch repair gene. We describe the case of 58‐year‐old man who, over the course of several years, had multiple skin lesions and colon cancer....

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Bibliographic Details
Published in:Clinical case reports 2022-03, Vol.10 (3), p.e05537-n/a
Main Authors: Ben Rejeb, Mohamed, Mokni, Sana, Ben Rejeb, Maha, Abdelmoula, Nihed, Sriha, Baderedine, Khochteli, Habib, Denguezli, Mohamed
Format: Article
Language:English
Subjects:
Case reports
Clinical Image
Clinical Images
Colorectal cancer
Consent
Information sharing
Muir‐Torre syndrome
Mutation
sebaceous tumors
Tumors
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Summary:The Muir‐Torre Syndrome is a rare genodermatosis, defined by the occurrence of sebaceous neoplasia and internal malignancies and caused by mutations in the mismatch repair gene. We describe the case of 58‐year‐old man who, over the course of several years, had multiple skin lesions and colon cancer. The syndrome was diagnosed using Sanger sequencing, which allowed us to find the causative mutation. Muir‐Torre syndrome is an autosomal‐dominant genodermatosis characterized by the occurrence of sebaceous neoplasia and visceral malignancy. Colorectal cancer is the commonest visceral malignancy associated with MTS. Metachronous sebaceous gland tumors after colorectal carcinoma along with suspicious family history should prompt genetic analysis for MTS and appropriate counseling of the family members.
ISSN:2050-0904
2050-0904
DOI:10.1002/ccr3.5537