Research Progress of Safety of Zearalenone: A Review

Zearalenone, a mycotoxin produced by fungi of the genus Fusarium, widely exists in animal feed and human food. The structure of zearalenone is similar to estrogen, so it mainly has estrogenic effects on various organisms. Products contaminated with zearalenone can pose risks to animals and humans. T...

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Bibliographic Details
Published in:Toxins 2022-06, Vol.14 (6), p.386
Main Authors: Han, Xiao, Huangfu, Bingxin, Xu, Tongxiao, Xu, Wentao, Asakiya, Charles, Huang, Kunlun, He, Xiaoyun
Format: Article
Language:English
Subjects:
Animal feed
Animals
Bile
Carcinogenicity
Carcinogens
Chemical properties
Climate change
endocrine interference
Enzymes
Estrogens
Feeds
Food contamination & poisoning
Hepatotoxicity
Immunotoxicity
intestinal health
Liver
Metabolism
Metabolites
mycotoxin
Mycotoxins
Ovaries
Poultry
Review
Risk assessment
Small intestine
Steroids
Toxicity
Urine
Xenoestrogens
Zearalenone
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Summary:Zearalenone, a mycotoxin produced by fungi of the genus Fusarium, widely exists in animal feed and human food. The structure of zearalenone is similar to estrogen, so it mainly has estrogenic effects on various organisms. Products contaminated with zearalenone can pose risks to animals and humans. Therefore, it is imperative to carry out toxicological research on zearalenone and evaluate its risk to human health. This paper briefly introduces the production, physical, and chemical properties of zearalenone and the research progress of its toxicity kinetics, focusing on its genetic toxicity, reproductive toxicity, hepatotoxicity, immunotoxicity, carcinogenicity, endocrine interference, and its impact on intestinal health. Finally, the progress of the risk assessment of human exposure is summarized to provide a reference for the follow-up study of zearalenone.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins14060386