Cancer-specific survival in patients with cholangiocarcinoma after radical surgery: a Novel, dynamic nomogram based on clinicopathological features and serum markers

This study aims to (1) identify preoperative testing-based characteristics associated with enhanced prognosis and survival for cholangiocarcinoma patients, and (2)create a distinctive nomogram to anticipate each patient's cancer-specific survival (CSS). Retrospective analysis was performed on 1...

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Bibliographic Details
Published in:BMC cancer 2023-06, Vol.23 (1), p.533-533, Article 533
Main Authors: Zhou, Shurui, Zhao, Yue, Lu, Yanzong, Liang, Weiling, Ruan, Jianmin, Lin, Lijun, Lin, Haoming, Huang, Kaihong
Format: Article
Language:English
Subjects:
Analysis
Antigens
Biomarkers
Blood platelets
Cancer
Cancer patients
Care and treatment
CEA (Oncology)
Chemotherapy
Cholangiocarcinoma
Decision making
Development and progression
Hospitals
Inflammation
Laboratories
Leukocytes
Lymph nodes
Lymphatic system
Medical prognosis
Medical records
Metastases
Metastasis
Mortality
Neutrophils
Nomogram
Nomograms
Nomography (Mathematics)
Patient outcomes
Patients
Prevention
Prognosis
Risk factors
Software
Statistical analysis
Surgery
Survival
Testing
Tumors
Variables
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Summary:This study aims to (1) identify preoperative testing-based characteristics associated with enhanced prognosis and survival for cholangiocarcinoma patients, and (2)create a distinctive nomogram to anticipate each patient's cancer-specific survival (CSS). Retrospective analysis was performed on 197 CCA patients who underwent radical surgery at Sun Yat-sen Memorial Hospital; they were divided into a 131-person "training cohort" and a 66-person "internal validation cohort." The prognostic nomogram was created following a preliminary Cox proportional hazard regression search for independent factors influencing the patients' CSS. Its applicable domain was examined via an external validation cohort, which included 235 patients from the Sun Yat-sen University Cancer Center. The median follow-up period for the 131 patients in the training group was 49.3 months (range, 9.3 to 133.9 months). One-, three-, and five-year CSS rates were 68.7%, 24.5%, and 9.2%, respectively, with the median CSS length being 27.4 months (range: 1.4 to 125.2 months). PLT, CEA, AFP, tumor location, differentiation, lymph node metastasis, chemotherapy, and TNM stage were determined to be independent risk factors for CCA patients by univariate and multivariate Cox proportional hazard regression analysis. We were able to accurately predict postoperative CSS after incorporating all of these characteristics into a nomogram. The AJCC's 8th edition staging method's C-indices were statistically substantially (P 
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-023-11040-9