The Effects of Time-Restricted Eating on Metabolism and Gut Microbiota: A Real-Life Study

The metabolic benefits of time-restricted eating (TRE) in humans are statistically significant but not clinically relevant. Few data are available about the effects of TRE on the gut microbiota. We compared the effects of a TRE regimen (12 h feeding; n = 24), on the clinical and dietary variables an...

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Published in:Nutrients 2022-06, Vol.14 (13), p.2569
Main Authors: Ferrocino, Ilario, Pellegrini, Marianna, D'Eusebio, Chiara, Goitre, Ilaria, Ponzo, Valentina, Fadda, Maurizio, Rosato, Rosalba, Mengozzi, Giulio, Beccuti, Guglielmo, Merlo, Fabio Dario, Rahimi, Farnaz, Comazzi, Isabella, Cocolin, Luca, Ghigo, Ezio, Bo, Simona
Format: Article
Language:English
Subjects:
Body weight loss
Caloric Restriction
Composition
Diet
Dietary restrictions
Dietitians
Eating
Endocrinology
Exercise
Food
Gastrointestinal Microbiome
Gastrointestinal surgery
gut microbiota
Humans
Intestinal microflora
Metabolism
Microbiota
Microorganisms
Obesity
Obesity - metabolism
Oils & fats
Physical fitness
Severe acute respiratory syndrome coronavirus 2
Statistical analysis
time-restricted eating
Weight control
Weight Loss
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Summary:The metabolic benefits of time-restricted eating (TRE) in humans are statistically significant but not clinically relevant. Few data are available about the effects of TRE on the gut microbiota. We compared the effects of a TRE regimen (12 h feeding; n = 24), on the clinical and dietary variables and gut-microbiota composition in patients with obesity, who were subjected for 12 weeks to the same caloric restriction. Median weight loss was 4.0 kg and 2.2 kg in the TRE and TUE groups, respectively, with a between-group borderline difference (p = 0.049). No significant between-group difference was found in other dietary, anthropometric, or laboratory variables. There were no substantial between-group differences in alpha and beta diversity or gut-microbiota composition. The TRE group showed a significant increase in the frequency of Lachnospiraceae, Parasutterella, and Romboutsia at the study’s end. A TRE regimen induced small changes both in metabolic/dietary variables and in the gut-microbiota composition, with respect to the TUE. The microbial changes we have found were of uncertain clinical significance.
ISSN:2072-6643
2072-6643
DOI:10.3390/nu14132569