Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients

DEFA1/DEFA3, genes encoding human neutrophil peptides (HNP) 1–3, display wide-ranging copy number variations (CNVs) and is functionally associated with innate immunity and infections. To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106...

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Published in:Mediators of inflammation 2018-01, Vol.2018 (2018), p.1-8
Main Authors: Hu, Zhiyong, Shu, Qiang, Fang, Xiangming, Wu, Shuijing, Li, Zhongwang, Wang, Ya, Chu, Lihua, Xu, Weize, Wang, Lifeng, Gu, Qiang, Zhao, Jialian, Xu, Jianguo
Format: Article
Language:English
Subjects:
Aged
alpha-Defensins - genetics
Antimicrobial agents
Bacteria
Copy number
Critical Illness
Dendritic cells
Deoxyribonucleic acid
Disease
Disease susceptibility
DNA
DNA Copy Number Variations - genetics
Drug resistance
Ethylenediaminetetraacetic acid
Female
Gene Dosage - genetics
Gene expression
Genetic aspects
Genetic Predisposition to Disease - genetics
Genomes
Gram-positive bacteria
Health aspects
Hospitals
Humans
Innate immunity
Intensive care
Laboratories
Male
Middle Aged
Multidrug resistant organisms
Neutrophils
Nosocomial infections
Patient safety
Physiology
Sepsis
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creator Hu, Zhiyong
Shu, Qiang
Fang, Xiangming
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Wang, Lifeng
Gu, Qiang
Zhao, Jialian
Xu, Jianguo
description DEFA1/DEFA3, genes encoding human neutrophil peptides (HNP) 1–3, display wide-ranging copy number variations (CNVs) and is functionally associated with innate immunity and infections. To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106 patients with HAIs and 109 controls in the intensive care unit (ICU) and examined their DEFA1/DEFA3 CNVs. DEFA1/DEFA3 copy number ranged from 2 to 16 per diploid genome in all 215 critically ill patients, with a median of 7 copies. In HAIs, DEFA1/DEFA3 CNV varied from 2 to 12 with a median of 6, which was significantly lower than that in controls (2 to 16 with a median of 8, p=0.017). Patients with lower DEFA1/DEFA3 copy number (CNV 
doi_str_mv 10.1155/2018/2152650
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To identify potential associations between DEFA1/DEFA3 CNV and hospital-acquired infections (HAIs), we enrolled 106 patients with HAIs and 109 controls in the intensive care unit (ICU) and examined their DEFA1/DEFA3 CNVs. DEFA1/DEFA3 copy number ranged from 2 to 16 per diploid genome in all 215 critically ill patients, with a median of 7 copies. In HAIs, DEFA1/DEFA3 CNV varied from 2 to 12 with a median of 6, which was significantly lower than that in controls (2 to 16 with a median of 8, p=0.017). Patients with lower DEFA1/DEFA3 copy number (CNV &lt; 7) were far more common in HAIs than in controls (52.8% in HAIs versus 35.8% in controls; p=0.014; OR, 2.010; 95% CI, 1.164–3.472). The area under the receiver operating characteristic (AUROC) of DEFA1/DEFA3 CNV combined with clinical characteristics to predict the incidence of HAIs was 0.763 (95% CI 0.700–0.827), showing strong predictive ability. Therefore, lower DEFA1/DEFA3 copy number contributes to higher susceptibility to HAIs in critically ill patients, and DEFA1/DEFA3 CNV is a significant hereditary factor for predicting HAIs.</abstract><cop>Cairo, Egypt</cop><pub>Hindawi Publishing Corporation</pub><pmid>29950924</pmid><doi>10.1155/2018/2152650</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-4106-6255</orcidid><orcidid>https://orcid.org/0000-0001-9033-2890</orcidid><oa>free_for_read</oa></addata></record>
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subjects Aged
alpha-Defensins - genetics
Antimicrobial agents
Bacteria
Copy number
Critical Illness
Dendritic cells
Deoxyribonucleic acid
Disease
Disease susceptibility
DNA
DNA Copy Number Variations - genetics
Drug resistance
Ethylenediaminetetraacetic acid
Female
Gene Dosage - genetics
Gene expression
Genetic aspects
Genetic Predisposition to Disease - genetics
Genomes
Gram-positive bacteria
Health aspects
Hospitals
Humans
Innate immunity
Intensive care
Laboratories
Male
Middle Aged
Multidrug resistant organisms
Neutrophils
Nosocomial infections
Patient safety
Physiology
Sepsis
title Low-Copy Number Polymorphism in DEFA1/DEFA3 Is Associated with Susceptibility to Hospital-Acquired Infections in Critically Ill Patients
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