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Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence
Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery. From 2000 to 2012, 6025 a...
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| Published in: | Clinical epidemiology 2020-01, Vol.12, p.977-987 |
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| container_title | Clinical epidemiology |
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| creator | Hung, Ming-Szu Chen, Yi-Chuan Huang, Tsung-Yu Ho, Dong-Ru Lee, Chuan-Pin Chen, Pau-Chung Yang, Yao-Hsu |
| description | Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery.
From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI).
The incidence of ED was higher in the lung cancer cohort compared to the non-lung cancer cohort (38.47 vs 28.28 per 10,000 person-years) with an adjusted IRR (aIRR) of 1.34 (95% CI: 1.06-1.70,
=0.014) after the confounders were adjusted for. An increased incidence of ED was observed in the lung cancer cohort aged 40-54 years (aIRR: 5.44, 95% CI: 2.25-13.15, |
| doi_str_mv | 10.2147/CLEP.S264439 |
| format | article |
| fullrecord | <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_b3cf090ee7214566bf30171a298c06d9</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A638814585</galeid><doaj_id>oai_doaj_org_article_b3cf090ee7214566bf30171a298c06d9</doaj_id><sourcerecordid>A638814585</sourcerecordid><originalsourceid>FETCH-LOGICAL-c533t-374a05a37a83c8575cd80c5fb7fc93338159c1746c1b574ea9069daf5d385463</originalsourceid><addsrcrecordid>eNptUk2L2zAQNaWlu2z31nMxFHqqU8kjWVIPhZCm24VAPzbQo5BlyVGwrV3JXth_X2WThgQqHTSM3jzmzZsse4vRrMSEfVqslj9nd2VFCIgX2SXGTBQYiHh5El9k1zFuUToAmDH0OruAUvCSVOVl9msZjB5dZ_KvT9FOQ4r9kM_taEJ-N4XWadXl62DU2JthzL3NV9PQ5gs1aBM-57-N6oo_PnRNvnx0jUnZN9krq7porg_vVbb-tlwvvherHze3i_mq0BRgLIARhagCpjhoThnVDUea2ppZLQCAYyo0ZqTSuKaMGCVQJRplaQOckgqusts9bePVVt4H16vwJL1y8jnhQytVGJ3ujKxBWySQMSzNjFZVbQFhhlUagkZVIxLXlz3X_VT3ptFJaVDdGen5z-A2svWPkhFBEOKJ4P2BIPiHycRRbv0UhiRflskaVkKZRB9RrUpducH6RKZ7F7WcV8B5ao7ThJr9B5VuY3qn_WBscuu84MNJwSY5Mm6i76adk_Ec-HEP1MHHGIw9KsRI7tZJ7tZJHtYpwd-dTuUI_rc88Bd21MF6</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2443723253</pqid></control><display><type>article</type><title>Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence</title><source>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</source><source>Taylor & Francis Open Access</source><source>PubMed Central Free</source><creator>Hung, Ming-Szu ; Chen, Yi-Chuan ; Huang, Tsung-Yu ; Ho, Dong-Ru ; Lee, Chuan-Pin ; Chen, Pau-Chung ; Yang, Yao-Hsu</creator><creatorcontrib>Hung, Ming-Szu ; Chen, Yi-Chuan ; Huang, Tsung-Yu ; Ho, Dong-Ru ; Lee, Chuan-Pin ; Chen, Pau-Chung ; Yang, Yao-Hsu</creatorcontrib><description>Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery.
From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI).
The incidence of ED was higher in the lung cancer cohort compared to the non-lung cancer cohort (38.47 vs 28.28 per 10,000 person-years) with an adjusted IRR (aIRR) of 1.34 (95% CI: 1.06-1.70,
=0.014) after the confounders were adjusted for. An increased incidence of ED was observed in the lung cancer cohort aged 40-54 years (aIRR: 5.44, 95% CI: 2.25-13.15,
<0.001), 55-64 years (aIRR: 3.62, 95% CI: 1.61-8.17,
=0.002) years, and anxiety (aIRR: 2.99, 95% CI: 1.81-4.94,
<0.001). In addition, a higher incidence of emergency room (ER) visits (aIRR: 2.19, 95% CI: 1.98-2.42,
<0.001) was observed in lung cancer patients with ED compared to those without ED.
Our study results suggested that early surveillance and intervention of ED should be advocated in lung cancer patients after surgery.</description><identifier>ISSN: 1179-1349</identifier><identifier>EISSN: 1179-1349</identifier><identifier>DOI: 10.2147/CLEP.S264439</identifier><identifier>PMID: 32982462</identifier><language>eng</language><publisher>New Zealand: Dove Medical Press Limited</publisher><subject>Age ; Anxiety ; Arthritis ; Asthma ; Cancer research ; Cancer therapies ; Cardiovascular disease ; Care and treatment ; Chronic obstructive pulmonary disease ; Clinical medicine ; Comorbidity ; Comparative analysis ; Diabetes ; Emergency medical services ; Epidemiology ; Erectile dysfunction ; Hypertension ; Impotence ; Kidney diseases ; Lung cancer ; Original Research ; Ostomy ; Patients ; Quality of life ; Respiratory system agents ; Risk factors ; Surgery ; Urbanization ; Weight control</subject><ispartof>Clinical epidemiology, 2020-01, Vol.12, p.977-987</ispartof><rights>2020 Hung et al.</rights><rights>COPYRIGHT 2020 Dove Medical Press Limited</rights><rights>2020. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2020 Hung et al. 2020 Hung et al.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c533t-374a05a37a83c8575cd80c5fb7fc93338159c1746c1b574ea9069daf5d385463</cites><orcidid>0000-0003-1998-5631 ; 0000-0001-6324-561X ; 0000-0002-8080-0504 ; 0000-0002-1805-0538 ; 0000-0002-6242-5974</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.proquest.com/docview/2443723253/fulltextPDF?pq-origsite=primo$$EPDF$$P50$$Gproquest$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.proquest.com/docview/2443723253?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,25753,27924,27925,37012,44590,53791,53793,75126</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/32982462$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hung, Ming-Szu</creatorcontrib><creatorcontrib>Chen, Yi-Chuan</creatorcontrib><creatorcontrib>Huang, Tsung-Yu</creatorcontrib><creatorcontrib>Ho, Dong-Ru</creatorcontrib><creatorcontrib>Lee, Chuan-Pin</creatorcontrib><creatorcontrib>Chen, Pau-Chung</creatorcontrib><creatorcontrib>Yang, Yao-Hsu</creatorcontrib><title>Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence</title><title>Clinical epidemiology</title><addtitle>Clin Epidemiol</addtitle><description>Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery.
From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI).
The incidence of ED was higher in the lung cancer cohort compared to the non-lung cancer cohort (38.47 vs 28.28 per 10,000 person-years) with an adjusted IRR (aIRR) of 1.34 (95% CI: 1.06-1.70,
=0.014) after the confounders were adjusted for. An increased incidence of ED was observed in the lung cancer cohort aged 40-54 years (aIRR: 5.44, 95% CI: 2.25-13.15,
<0.001), 55-64 years (aIRR: 3.62, 95% CI: 1.61-8.17,
=0.002) years, and anxiety (aIRR: 2.99, 95% CI: 1.81-4.94,
<0.001). In addition, a higher incidence of emergency room (ER) visits (aIRR: 2.19, 95% CI: 1.98-2.42,
<0.001) was observed in lung cancer patients with ED compared to those without ED.
Our study results suggested that early surveillance and intervention of ED should be advocated in lung cancer patients after surgery.</description><subject>Age</subject><subject>Anxiety</subject><subject>Arthritis</subject><subject>Asthma</subject><subject>Cancer research</subject><subject>Cancer therapies</subject><subject>Cardiovascular disease</subject><subject>Care and treatment</subject><subject>Chronic obstructive pulmonary disease</subject><subject>Clinical medicine</subject><subject>Comorbidity</subject><subject>Comparative analysis</subject><subject>Diabetes</subject><subject>Emergency medical services</subject><subject>Epidemiology</subject><subject>Erectile dysfunction</subject><subject>Hypertension</subject><subject>Impotence</subject><subject>Kidney diseases</subject><subject>Lung cancer</subject><subject>Original Research</subject><subject>Ostomy</subject><subject>Patients</subject><subject>Quality of life</subject><subject>Respiratory system agents</subject><subject>Risk factors</subject><subject>Surgery</subject><subject>Urbanization</subject><subject>Weight control</subject><issn>1179-1349</issn><issn>1179-1349</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><sourceid>DOA</sourceid><recordid>eNptUk2L2zAQNaWlu2z31nMxFHqqU8kjWVIPhZCm24VAPzbQo5BlyVGwrV3JXth_X2WThgQqHTSM3jzmzZsse4vRrMSEfVqslj9nd2VFCIgX2SXGTBQYiHh5El9k1zFuUToAmDH0OruAUvCSVOVl9msZjB5dZ_KvT9FOQ4r9kM_taEJ-N4XWadXl62DU2JthzL3NV9PQ5gs1aBM-57-N6oo_PnRNvnx0jUnZN9krq7porg_vVbb-tlwvvherHze3i_mq0BRgLIARhagCpjhoThnVDUea2ppZLQCAYyo0ZqTSuKaMGCVQJRplaQOckgqusts9bePVVt4H16vwJL1y8jnhQytVGJ3ujKxBWySQMSzNjFZVbQFhhlUagkZVIxLXlz3X_VT3ptFJaVDdGen5z-A2svWPkhFBEOKJ4P2BIPiHycRRbv0UhiRflskaVkKZRB9RrUpducH6RKZ7F7WcV8B5ao7ThJr9B5VuY3qn_WBscuu84MNJwSY5Mm6i76adk_Ec-HEP1MHHGIw9KsRI7tZJ7tZJHtYpwd-dTuUI_rc88Bd21MF6</recordid><startdate>20200101</startdate><enddate>20200101</enddate><creator>Hung, Ming-Szu</creator><creator>Chen, Yi-Chuan</creator><creator>Huang, Tsung-Yu</creator><creator>Ho, Dong-Ru</creator><creator>Lee, Chuan-Pin</creator><creator>Chen, Pau-Chung</creator><creator>Yang, Yao-Hsu</creator><general>Dove Medical Press Limited</general><general>Taylor & Francis Ltd</general><general>Dove</general><general>Dove Medical Press</general><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7XB</scope><scope>8C1</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>5PM</scope><scope>DOA</scope><orcidid>https://orcid.org/0000-0003-1998-5631</orcidid><orcidid>https://orcid.org/0000-0001-6324-561X</orcidid><orcidid>https://orcid.org/0000-0002-8080-0504</orcidid><orcidid>https://orcid.org/0000-0002-1805-0538</orcidid><orcidid>https://orcid.org/0000-0002-6242-5974</orcidid></search><sort><creationdate>20200101</creationdate><title>Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence</title><author>Hung, Ming-Szu ; Chen, Yi-Chuan ; Huang, Tsung-Yu ; Ho, Dong-Ru ; Lee, Chuan-Pin ; Chen, Pau-Chung ; Yang, Yao-Hsu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c533t-374a05a37a83c8575cd80c5fb7fc93338159c1746c1b574ea9069daf5d385463</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Age</topic><topic>Anxiety</topic><topic>Arthritis</topic><topic>Asthma</topic><topic>Cancer research</topic><topic>Cancer therapies</topic><topic>Cardiovascular disease</topic><topic>Care and treatment</topic><topic>Chronic obstructive pulmonary disease</topic><topic>Clinical medicine</topic><topic>Comorbidity</topic><topic>Comparative analysis</topic><topic>Diabetes</topic><topic>Emergency medical services</topic><topic>Epidemiology</topic><topic>Erectile dysfunction</topic><topic>Hypertension</topic><topic>Impotence</topic><topic>Kidney diseases</topic><topic>Lung cancer</topic><topic>Original Research</topic><topic>Ostomy</topic><topic>Patients</topic><topic>Quality of life</topic><topic>Respiratory system agents</topic><topic>Risk factors</topic><topic>Surgery</topic><topic>Urbanization</topic><topic>Weight control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hung, Ming-Szu</creatorcontrib><creatorcontrib>Chen, Yi-Chuan</creatorcontrib><creatorcontrib>Huang, Tsung-Yu</creatorcontrib><creatorcontrib>Ho, Dong-Ru</creatorcontrib><creatorcontrib>Lee, Chuan-Pin</creatorcontrib><creatorcontrib>Chen, Pau-Chung</creatorcontrib><creatorcontrib>Yang, Yao-Hsu</creatorcontrib><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Public Health Database</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>AUTh Library subscriptions: ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>Research Library (ProQuest)</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database (Proquest) (PQ_SDU_P3)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Clinical epidemiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hung, Ming-Szu</au><au>Chen, Yi-Chuan</au><au>Huang, Tsung-Yu</au><au>Ho, Dong-Ru</au><au>Lee, Chuan-Pin</au><au>Chen, Pau-Chung</au><au>Yang, Yao-Hsu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence</atitle><jtitle>Clinical epidemiology</jtitle><addtitle>Clin Epidemiol</addtitle><date>2020-01-01</date><risdate>2020</risdate><volume>12</volume><spage>977</spage><epage>987</epage><pages>977-987</pages><issn>1179-1349</issn><eissn>1179-1349</eissn><abstract>Sexual problems are common in male lung cancer survivors. However, the development of erectile dysfunction (ED) in lung cancer patients after surgery has been rarely explored. In this study, we aimed to explore the incidence and risk factors of ED after lung cancer surgery.
From 2000 to 2012, 6025 and 24,100 male patients were included in each matched cohort of lung cancer and non-lung cancer patients, respectively. Poisson regression analysis was used to calculate the incidence rate ratio (IRR) and 95% confidence interval (CI).
The incidence of ED was higher in the lung cancer cohort compared to the non-lung cancer cohort (38.47 vs 28.28 per 10,000 person-years) with an adjusted IRR (aIRR) of 1.34 (95% CI: 1.06-1.70,
=0.014) after the confounders were adjusted for. An increased incidence of ED was observed in the lung cancer cohort aged 40-54 years (aIRR: 5.44, 95% CI: 2.25-13.15,
<0.001), 55-64 years (aIRR: 3.62, 95% CI: 1.61-8.17,
=0.002) years, and anxiety (aIRR: 2.99, 95% CI: 1.81-4.94,
<0.001). In addition, a higher incidence of emergency room (ER) visits (aIRR: 2.19, 95% CI: 1.98-2.42,
<0.001) was observed in lung cancer patients with ED compared to those without ED.
Our study results suggested that early surveillance and intervention of ED should be advocated in lung cancer patients after surgery.</abstract><cop>New Zealand</cop><pub>Dove Medical Press Limited</pub><pmid>32982462</pmid><doi>10.2147/CLEP.S264439</doi><tpages>11</tpages><orcidid>https://orcid.org/0000-0003-1998-5631</orcidid><orcidid>https://orcid.org/0000-0001-6324-561X</orcidid><orcidid>https://orcid.org/0000-0002-8080-0504</orcidid><orcidid>https://orcid.org/0000-0002-1805-0538</orcidid><orcidid>https://orcid.org/0000-0002-6242-5974</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Age Anxiety Arthritis Asthma Cancer research Cancer therapies Cardiovascular disease Care and treatment Chronic obstructive pulmonary disease Clinical medicine Comorbidity Comparative analysis Diabetes Emergency medical services Epidemiology Erectile dysfunction Hypertension Impotence Kidney diseases Lung cancer Original Research Ostomy Patients Quality of life Respiratory system agents Risk factors Surgery Urbanization Weight control |
| title | Erectile Dysfunction After Surgical Treatment of Lung Cancer: Real-World Evidence |
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