Marburg virus pathogenesis - differences and similarities in humans and animal models

Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients. There are currently no approved vaccines or treat...

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Bibliographic Details
Published in:Virology journal 2019-12, Vol.16 (1), p.165-165, Article 165
Main Authors: Shifflett, Kyle, Marzi, Andrea
Format: Article
Language:English
Subjects:
Analysis
Animal models
Animals
Antigens
Care and treatment
Clinical trials
Disease
Disease Models, Animal
disease severity
Epidemics
Fatalities
Fever
Filovirus
Genomes
Health aspects
Hemorrhage
Host-Pathogen Interactions
Human pathogenesis
humans
Infections
Infectious diseases
Kidneys
Laboratories
Lymphatic system
Marburg disease
Marburg marburgvirus
Marburg virus disease
Marburg Virus Disease - physiopathology
Marburgvirus
Marburgvirus - growth & development
Marburgvirus - pathogenicity
MARV
Medical research
mortality
Outbreaks
Pathogenesis
Pathogens
patients
Review
Spleen
Vaccines
virulent strains
Virus diseases
Viruses
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Summary:Marburg virus (MARV) is a highly pathogenic virus associated with severe disease and mortality rates as high as 90%. Outbreaks of MARV are sporadic, deadly, and often characterized by a lack of resources and facilities to diagnose and treat patients. There are currently no approved vaccines or treatments, and the chaotic and infrequent nature of outbreaks, among other factors, makes testing new countermeasures during outbreaks ethically and logistically challenging. Without field efficacy studies, researchers must rely on animal models of MARV infection to assess the efficacy of vaccines and treatments, with the limitations being the accuracy of the animal model in recapitulating human pathogenesis. This review will compare various animal models to the available descriptions of human pathogenesis and aims to evaluate their effectiveness in modeling important aspects of Marburg virus disease.
ISSN:1743-422X
1743-422X
DOI:10.1186/s12985-019-1272-z