Androgens added to immunosuppressive regimen in patients with aplastic anaemia. A retrospective study

Abstract Background Androgens have been used to treat bone marrow failure syndromes such as aplastic anaemia (AA) since the 1970s, and are currently used as adjuvants to other treatment regimens. Objective To determine the efficacy and response time of androgens in the treatment of AA. Materials and...

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Bibliographic Details
Published in:Revista medica del hospital general de mexico s.s.a 2015-07, Vol.78 (3), p.107-111
Main Authors: Ramos-Peñafiel, C.O, Ferrer-Argote, V.E, Trejo-Ayala, R, León-González, G, Santoyo-Sánchez, A, Collazo-Jaloma, J
Format: Article
Language:English
Subjects:
Androgens
Andrógenos
Anemia aplásica
Aplastic anaemia
Cohort study
Estudio de cohorte
Immunosupression
Inmunosupresión
Medical/Surgical
Resultado del tratamiento
Treatment outcome
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Summary:Abstract Background Androgens have been used to treat bone marrow failure syndromes such as aplastic anaemia (AA) since the 1970s, and are currently used as adjuvants to other treatment regimens. Objective To determine the efficacy and response time of androgens in the treatment of AA. Materials and methods A retrospective, analytical-observational nested study in a cohort of patients with AA. The study was conducted from January 2006 to December 2013. Results A total of 63 patients with a mean age of 47 (18–83) years were included in the study. Out of 27 patients in full remission, 17 received some type of immunosuppressant combined with androgens. The use of more than 2 immunosuppressants did not significantly improve response times ( p = 0.311, 95% CI). Mean response time was 725 (331–1119) days; 4-year survival rate was 86%. Conclusions Improved immunosuppressant response rates with adjuvant androgens were mainly observed in patients with severe AA.
ISSN:0185-1063
DOI:10.1016/j.hgmx.2015.07.002