Starvation decreases immunity and immune regulatory factor NF-κB in the starlet sea anemone Nematostella vectensis

• Published in: Communications biology 2023-07, Vol.6 (1), p.698-698, Article 698
• Main Authors: Carrión, Pablo J. Aguirre, Desai, Niharika, Brennan, Joseph J., Fifer, James E., Siggers, Trevor, Davies, Sarah W., Gilmore, Thomas D.
• Format: Article
• Language: English
• Subjects: 13; 13/51; 38; 38/1; 38/39; 38/91; 631/181/735; 631/250/262; 64; 82; 82/1; 82/51; 82/80; 96; 96/1; 96/106; 96/109; 96/95; Animals; Biology; Biomedical and Life Sciences; Down-regulation; Gene expression; Gene Expression Profiling; Gene Expression Regulation; Immunity; Life Sciences; Marine organisms; Nematostella vectensis; NF-kappa B - genetics; NF-kappa B - metabolism; NF-κB protein; Nutrition; Nutritional status; Sea Anemones - genetics; Sea Anemones - metabolism; Starvation
• ISSN: 2399-3642; 2399-3642
• DOI: 10.1038/s42003-023-05084-7

Lack of proper nutrition has important consequences for the physiology of all organisms, and nutritional status can affect immunity, based on many studies in terrestrial animals. Here we show a positive correlation between nutrition and immunity in the sea anemone Nematostella vectensis . Gene expression profiling of adult anemones shows downregulation of genes involved in nutrient metabolism, cellular respiration, and immunity in starved animals. Starved adult anemones also have reduced protein levels and activity of immunity transcription factor NF-κB. Starved juvenile anemones have increased sensitivity to bacterial infection and also have lower NF-κB protein levels, as compared to fed controls. Weighted Gene Correlation Network Analysis (WGCNA) is used to identify significantly correlated gene networks that were downregulated with starvation. These experiments demonstrate a correlation between nutrition and immunity in an early diverged marine metazoan, and the results have implications for the survival of marine organisms as they encounter changing environments. Starvation is found to decrease immunity via effects on NF-κB in the Starlet Sea Anemone Nematostella vectensis, advancing our understanding of the correlation between nutrition and immunity in marine metazoans.