Invited review: Genetic and genomic mouse models for livestock research

Knowledge about the function and functioning of single or multiple interacting genes is of the utmost significance for understanding the organism as a whole and for accurate livestock improvement through genomic selection. This includes, but is not limited to, understanding the ontogenetic and envir...

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Bibliographic Details
Published in:Archiv für Tierzucht 2018-02, Vol.61 (1), p.87-98
Main Authors: Arends, Danny, Hesse, Deike, Brockmann, Gudrun A
Format: Article
Language:English
Subjects:
Agricultural research
Animal models
Complexity
Gene expression
Genes
Genetic modification
Genetically modified mice
Genetically modified organisms
Genetics
Heredity
Livestock
Livestock industry
Mice
Ontogeny
Physiological aspects
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Summary:Knowledge about the function and functioning of single or multiple interacting genes is of the utmost significance for understanding the organism as a whole and for accurate livestock improvement through genomic selection. This includes, but is not limited to, understanding the ontogenetic and environmentally driven regulation of gene action contributing to simple and complex traits. Genetically modified mice, in which the functions of single genes are annotated; mice with reduced genetic complexity; and simplified structured populations are tools to gain fundamental knowledge of inheritance patterns and whole system genetics and genomics. In this review, we briefly describe existing mouse resources and discuss their value for fundamental and applied research in livestock.
ISSN:2363-9822
0003-9438
2363-9822
DOI:10.5194/aab-61-87-2018