Lipid metabolism in tumor immunology and immunotherapy

Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their...

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Bibliographic Details
Published in:Frontiers in oncology 2023-05, Vol.13, p.1187279
Main Authors: Duong, Lisa K, Corbali, Halil Ibrahim, Riad, Thomas S, Ganjoo, Shonik, Nanez, Selene, Voss, Tiffany, Barsomium, Hampartsum, Welsh, James, Cortez, Maria Angelica
Format: Article
Language:English
Subjects:
cancer
immune cells
immunotherapy
lipid oxidation
lipids
Oncology
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Summary:Lipids are a diverse class of biomolecules that have been implicated in cancer pathophysiology and in an array of immune responses, making them potential targets for improving immune responsiveness. Lipid and lipid oxidation also can affect tumor progression and response to treatment. Although their importance in cellular functions and their potential as cancer biomarkers have been explored, lipids have yet to be extensively investigated as a possible form of cancer therapy. This review explores the role of lipids in cancer pathophysiology and describes how further understanding of these macromolecules could prompt novel treatments for cancer.
ISSN:2234-943X
2234-943X
DOI:10.3389/fonc.2023.1187279