Prophylactic effect of low dose vitamin D in osteopenia of prematurity: a clinical trial study

Osteopenia of prematurity (OOP) is a preventable disease. Improved survival of premature newborns is associated with an increased incidence of OOP. The purpose of this study was to compare the prophylactic effects of two low doses of vitamin D (200 and 400 IU/Day) on the clinical, biochemical and ra...

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Bibliographic Details
Published in:Acta medica Iranica 2014, Vol.52 (9), p.671-674
Main Authors: Alizadeh Taheri, Paymaneh, Sajjadian, Negar, Beyrami, Bahram, Shariat, Mamak
Format: Article
Language:English
Subjects:
Bone Diseases, Metabolic - prevention & control
Dose
Female
Gestational Age
Humans
Infant, Newborn
Infant, Premature
Infant, Premature, Diseases - prevention & control
Infant, Very Low Birth Weight
Male
Osteopenia
Phosphates - blood
Prematurity
Rickets - prevention & control
Vitamin D
Vitamin D - administration & dosage
Vitamin D - analogs & derivatives
Vitamin D - blood
Vitamins - administration & dosage
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Summary:Osteopenia of prematurity (OOP) is a preventable disease. Improved survival of premature newborns is associated with an increased incidence of OOP. The purpose of this study was to compare the prophylactic effects of two low doses of vitamin D (200 and 400 IU/Day) on the clinical, biochemical and radiological indices of the rickets of prematurity. In a randomized clinical trial, 60 preterm newborns with birth weight < 2000 g & gestational age < 37 weeks were randomly divided in two groups. Thirty newborns received 200 IU/d of vitamin D in group one and 30 ones received 400 IU/day of vitamin D in group two. On the 6th to 8th weeks of life, serum calcium, phosphate, alkaline phosphates, and 25-hydroxy vitamin D concentrations were measured and x- ray of left wrist and physical examination were performed. Both groups had no difference in biochemical, radiological or clinical presentation of rickets. Current study indicated that low dose vitamin D (200 IU/Day) is enough for prevention of OOP.
ISSN:0044-6025
1735-9694