Association of systemic inflammatory indices with anthropometric measures, metabolic factors, and liver function in non-alcoholic fatty liver disease

The present cross-sectional study aimed to explore the relationship between systemic inflammatory indices (SIIs) and anthropometric measures, metabolic, and liver function biomarkers in patients with non-alcoholic fatty liver disease (NAFLD). This study was carried out on 238 NAFLD patients with ove...

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Bibliographic Details
Published in:Scientific reports 2024-06, Vol.14 (1), p.12829-12829
Main Authors: Arefhosseini, Sara, Aghajani, Taha, Tutunchi, Helda, Ebrahimi-Mameghani, Mehrangiz
Format: Article
Language:English
Subjects:
692/163/2743/2037
692/163/2743/2099
692/163/2743/393
692/4020/4021/1607/2750
Adolescent
Adult
Anthropometry
Biomarkers
Biomarkers - blood
Blood Glucose - metabolism
Body Mass Index
Cholesterol
Cross-Sectional Studies
Fasting
Fatty liver
Female
High density lipoprotein
Humanities and Social Sciences
Humans
Inflammation
Inflammation - blood
Inflammation - metabolism
Leukocytes (neutrophilic)
Liver
Liver - metabolism
Liver - pathology
Liver diseases
Liver function
Liver Function Tests
Lymphocytes
Male
Metabolic factors
Metabolism
Middle Aged
Monocytes
multidisciplinary
Non-alcoholic fatty liver disease
Non-alcoholic Fatty Liver Disease - blood
Non-alcoholic Fatty Liver Disease - metabolism
Obesity - blood
Obesity - complications
Obesity - metabolism
Risk factors
Science
Science (multidisciplinary)
Steatosis
Systemic inflammatory indices
Triglycerides
Waist-Hip Ratio
Young Adult
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Summary:The present cross-sectional study aimed to explore the relationship between systemic inflammatory indices (SIIs) and anthropometric measures, metabolic, and liver function biomarkers in patients with non-alcoholic fatty liver disease (NAFLD). This study was carried out on 238 NAFLD patients with overweight or obesity, aged 18–55 years. Anthropometric measurements were done and body mass index (BMI), waist-to-hip ratio (WHR), and waist-to-height ratio (WHtR) were estimated. Metabolic factors including serum glucose, lipid profile, liver function biomarkers, and complete blood cell count were assessed after a 24-h fasting state. SIIs including the ratios of neutrophil to lymphocyte (NLR), monocytes to lymphocyte (MLR), platelet to lymphocyte (PLR), and monocytes to high-density lipoprotein cholesterol (MHR) were calculated. Results indicate that apart from PLR, all of the SIIs significantly changed by increasing steatosis severity (all p  
ISSN:2045-2322
DOI:10.1038/s41598-024-63381-5