Understanding the tumor microenvironment in head and neck squamous cell carcinoma

Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of tumors. While significant progress has been made using multimodal treatment, the 5‐year survival remains at 50%. Developing effective therapies, such as immunotherapy, will likely lead to better treatment of primary an...

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Bibliographic Details
Published in:Clinical & translational immunology 2022, Vol.11 (6), p.e1397-n/a
Main Authors: Rad, Habib Sadeghi, Shiravand, Yavar, Radfar, Payar, Ladwa, Rahul, Perry, Chris, Han, Xiaoyuan, Warkiani, Majid Ebrahimi, Adams, Mark N, Hughes, Brett GM, O'Byrne, Ken, Kulasinghe, Arutha
Format: Article
Language:English
Subjects:
Apoptosis
biomarkers
Cancer
Cell cycle
Chemokines
Clinical outcomes
Cyclin-dependent kinases
Cytotoxicity
Epigenetics
Fibroblasts
Genomes
Genotype & phenotype
Growth factors
Head & neck cancer
Head and neck carcinoma
head and neck squamous cell carcinoma
Human papillomavirus
Immune checkpoint
immune checkpoint inhibitors
Immunotherapy
Kinases
Lymphocytes
Medical prognosis
Metastases
Metastasis
Mutation
Proteins
Radiation therapy
Review
Reviews
Signal transduction
Squamous cell carcinoma
Treatment resistance
Tumor microenvironment
Tumor necrosis factor-TNF
Tumors
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Summary:Head and neck squamous cell carcinoma (HNSCC) represents a heterogeneous group of tumors. While significant progress has been made using multimodal treatment, the 5‐year survival remains at 50%. Developing effective therapies, such as immunotherapy, will likely lead to better treatment of primary and metastatic disease. However, not all HNSCC tumors respond to immune checkpoint blockade therapy. Understanding the complex cellular composition and interactions of the tumor microenvironment is likely to lead to new knowledge for effective therapies and treatment resistance. In this review, we discuss HNSCC characteristics, predictive biomarkers, factors influencing immunotherapy response, with a focus on the tumor microenvironment. This manuscript describes the tumor microenvironment of head and neck cancers that is integral for understanding effective therapies.
ISSN:2050-0068
2050-0068
DOI:10.1002/cti2.1397