Clinical comparison of HMPV and RSV infections in hospitalised Malaysian children: A propensity score matched study

Introduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical...

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Published in:The clinical respiratory journal 2024-03, Vol.18 (3), p.e13747-n/a
Main Authors: Ng, David Chun‐Ern, Liew, Chuin‐Hen, Tan, Kah Kee, Awang, Elida Hanan binti, Nazri, Farah Nuruliayana binti Ahmad, Maran, Asuwani K. Tamil, Mohan, Vishnu Arvindran a/l Chandra, Ramachandran, Durairaaj, Chok, Michelle, Teh, Cheah Hooi, Mohamad Nor, Airena, Baharuddin, Suhaila bt, Khoo, Erwin Jiayuan
Format: Article
Language:English
Subjects:
Adolescent
Adrenal Cortex Hormones
Adult
Child
hMPV
Humans
Infant
Infections
Metapneumovirus
Original
paediatric
Paramyxoviridae Infections - diagnosis
Paramyxoviridae Infections - epidemiology
predictors
Propensity Score
Respiratory syncytial virus
Respiratory Syncytial Virus Infections - diagnosis
Respiratory Syncytial Virus Infections - epidemiology
Respiratory Syncytial Virus, Human
Respiratory Tract Infections - epidemiology
Retrospective Studies
RSV
severity
Steroids
Young Adult
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Summary:Introduction Human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) are significant contributors to the burden of acute respiratory infections in children, but data on hMPV from Southeast Asia are limited despite its potential for serious disease. This study aimed to compare the clinical presentation, resource utilisation and outcomes between hMPV and RSV infections in hospitalised Malaysian children. Methods This retrospective, observational study included children aged ≤12 years old hospitalised with hMPV or RSV, confirmed via direct fluorescent antibody (DFA) methods, between 1 July to 30 October 2022 at Hospital Tuanku Ja'afar Seremban, Malaysia. Demographic, clinical presentation, resource utilisation and outcome data were analysed. Propensity score matching was used to balance cohorts based on key demographic and clinical characteristics. Results This study included 192 patients, comprising 112 with hMPV and 80 with RSV. hMPV patients were older (median age 20.5 vs. 9.4 months, p 
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.13747