Septicemia after chemotherapy for childhood acute lymphoblastic leukemia in China: A multicenter study CCCG‐ALL‐2015

Background Septicemia is an important cause of treatment‐related mortality and treatment failure in pediatric acute lymphoblastic leukemia (ALL) in developing countries. A multicenter CCCG‐ALL‐2015 study was conducted in China and factors associated with septicemia and mortality were studied. Method...

Full description

Saved in:
Bibliographic Details
Published in:Cancer medicine (Malden, MA) MA), 2020-03, Vol.9 (6), p.2113-2121
Main Authors: Zhu, Yiping, Yang, Rong, Cai, Jiaoyang, Yu, Jie, Tang, Yanjing, Chen, Yumei, Wang, Ningling, He, Hailong, Wu, Xuedong, Cheng, Frankie W. T., Sun, Lirong, He, Yingyi, Ju, Xiuli, Tian, Xin, Hu, Qun, Jin, Runming, Pan, Kaili, Fang, Yongjun, Zhai, Xiaowen, Jiang, Hui, Li, Chi‐kong
Format: Article
Language:English
Subjects:
Acute lymphoblastic leukemia
Adolescent
Age
Antibiotics
Antineoplastic Combined Chemotherapy Protocols - adverse effects
Bacteremia - blood
Bacteremia - epidemiology
Bacteremia - etiology
Bacteria
Chemotherapy
Child
Child, Preschool
Childhood
Children
China - epidemiology
Clinical Cancer Research
Computer centers
Consolidation Chemotherapy - adverse effects
Consolidation Chemotherapy - methods
Developing countries
Disease control
E coli
Female
Females
Fungemia - blood
Fungemia - epidemiology
Fungemia - etiology
Fungi
Gender
Gram-negative bacteria
Humans
Incidence
Induction Chemotherapy - adverse effects
Induction Chemotherapy - methods
Infant
Laboratories
LDCs
Leukemia
Lymphatic leukemia
Maintenance Chemotherapy - adverse effects
Maintenance Chemotherapy - methods
Male
Mortality
multicenter study
Original Research
Patients
Precursor Cell Lymphoblastic Leukemia-Lymphoma - blood
Precursor Cell Lymphoblastic Leukemia-Lymphoma - drug therapy
Precursor Cell Lymphoblastic Leukemia-Lymphoma - mortality
Prospective Studies
Retrospective Studies
Risk Factors
Sepsis
Septicemia
Sex Factors
Streptococcus infections
Studies
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Septicemia is an important cause of treatment‐related mortality and treatment failure in pediatric acute lymphoblastic leukemia (ALL) in developing countries. A multicenter CCCG‐ALL‐2015 study was conducted in China and factors associated with septicemia and mortality were studied. Methods Patients participated in CCCG‐ALL‐2015 study from January 2015 to December 2017 were included. Patients with documented septicemia were identified from the Data Center and additional data were collected. Results A total of 4080 patients were recruited in the study and 527 patients with septicemia were identified (12.9%, 95% CI 11.9%‐13.9%). The intermediate risk (IR)/high risk (HR) group had significantly higher incidence of septicemia as compared with low risk (LR) group, 17.1% vs 9.1% (OR 2.07, 95% CI 1.71‐2.49, P 
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.2889