Heterogeneity in Hematological Parameters of High and Low Altitude Tibetan Populations

High altitude hypoxia is believed to be experienced at elevations of more than 2500 meters above sea level. Several studies have shed light on the biochemical aspects of high altitude acclimatization, where participants were sojourners to the high altitude from low altitude areas. However, informati...

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Bibliographic Details
Published in:Journal of blood medicine 2021-01, Vol.12, p.287-298
Main Authors: Basak, Nipa, Norboo, Tsering, Mustak, Mohammed S, Thangaraj, Kumarasamy
Format: Article
Language:English
Subjects:
Adaptation
Age
Altitude
Analysis
Atmospheric pressure
Body mass index
Edema
Erythropoietin
Ethylenediaminetetraacetic acid
Glycosylated hemoglobin
hematological parameters
Hematology
Hemoglobin
high altitude
Hyperoxia
Hypoxia
low altitude
Migration
Normal distribution
Original Research
Physiology
Sea level
tibetans
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Summary:High altitude hypoxia is believed to be experienced at elevations of more than 2500 meters above sea level. Several studies have shed light on the biochemical aspects of high altitude acclimatization, where participants were sojourners to the high altitude from low altitude areas. However, information regarding the difference between the high altitude adapted Tibetans living at high altitude and their counterparts who reside at low altitude are lacking. To understand this, we have measured various hematological parameters in the Tibetan populations, who are residing in both high and low altitudes in India. A total of 168 individuals (79 from high altitude (≥4500 meters) and 89 from low altitude (~850 meters) were recruited for this study. Hematological parameters such as red blood cells (RBC) count, hematocrit (HCT), hemoglobin concentration (Hb), mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH) and mean corpuscular hemoglobin concentration (MCHC) were measured from the individuals from high and low altitudes. Serum erythropoietin (EPO) was measured by ELISA. Statistical analyses were performed to compare data from both of the altitudes. Gender-wise comparison of data was reported. Correlation analysis was performed within relevant parameters. Highly significant differences (p
ISSN:1179-2736
1179-2736
DOI:10.2147/JBM.S294564