Antidiabetic, Lipid Normalizing, and Nephroprotective Actions of the Strawberry: A Potent Supplementary Fruit

• Published in: International journal of molecular sciences 2017-01, Vol.18 (1), p.124-124
• Main Authors: Mandave, Pallavi, Khadke, Suresh, Karandikar, Manjiri, Pandit, Vijaya, Ranjekar, Prabhakar, Kuvalekar, Aniket, Mantri, Nitin
• Format: Article
• Language: English
• Subjects: Animals; Antidiabetics; antihyperglycemic activity; Antioxidants; Antioxidants - pharmacology; Biomarkers; Blood Glucose - drug effects; Creatinine; Diabetes; Diabetes mellitus; Diabetes Mellitus, Experimental; Dietary Supplements; Disease Models, Animal; Fragaria; Fragaria - chemistry; Gene expression; Gene Expression Regulation - drug effects; Genes; Hypoglycemic Agents - pharmacology; Inflammation; Inflammation Mediators - metabolism; Interleukin 6; Kidney - drug effects; Kidney - metabolism; Lipid Metabolism - drug effects; Lipid Metabolism - genetics; Lipids; Lipids - blood; Liver; Liver - drug effects; Liver - metabolism; Male; Nicotinamide; Normalizing; normolipidemic activity; Oxidation-Reduction - drug effects; Oxidative stress; Peroxisome proliferator-activated receptors; Plant Extracts - pharmacology; Polymerase chain reaction; Protective Agents - pharmacology; Rats; Regulatory sequences; Rodents; Sterol regulatory element-binding protein; Strawberries; strawberry; Streptozocin; Transcription factors; Tumor necrosis factor-TNF; Tumor necrosis factor-α; β-cell regeneration/protection effects
• ISSN: 1422-0067; 1661-6596; 1422-0067
• DOI: 10.3390/ijms18010124

The study was designed to assess the effect of different strawberry extracts on glucose levels, lipid profiles, and oxidative stress in nicotinamide-streptozotocin (NIC-STZ) induced diabetic rats. The associated changes were evaluated through biochemical, molecular, and histological assays. Diabetes was induced by intraperitoneal injection of STZ to albino Wistar rats after treatment with nicotinamide. Aqueous, hydroalcoholic, and alcoholic strawberry extracts were administrated orally to diabetic rats. Treatment of strawberry extracts improved lipid profile, liver function, and serum creatinine and led to a significant increase in antioxidant status in diabetic rats. Real-time PCR expression analysis of genes from the liver of animals treated with strawberry extracts exhibited downregulation of several fatty acid synthesis genes, transcription factors, such as Sterol regulatory Element Binding Transcription factor ( ) and Nuclear Factor-κβ ( ), and inflammatory markers, like Interleukin 6 ( ) and Tumor Necrosis Factor-α ( ). Strawberry extracts also upregulated liver Peroxisome Proliferator Activated Receptor-γ ( ). Histological examination confirmed the nephroprotective and β-cell regeneration/protection effects of strawberry extracts. The present study demonstrates several beneficial effects of strawberry extracts along with its probable mechanism of action.