ASXL1 mutations in younger adult patients with acute myeloid leukemia: a study by the German-Austrian Acute Myeloid Leukemia Study Group

• Published in: Haematologica (Roma) 2015-03, Vol.100 (3), p.324-330
• Main Authors: Paschka, Peter, Schlenk, Richard F, Gaidzik, Verena I, Herzig, Julia K, Aulitzky, Teresa, Bullinger, Lars, Späth, Daniela, Teleanu, Veronika, Kündgen, Andrea, Köhne, Claus-Henning, Brossart, Peter, Held, Gerhard, Horst, Heinz-A, Ringhoffer, Mark, Götze, Katharina, Nachbaur, David, Kindler, Thomas, Heuser, Michael, Thol, Felicitas, Ganser, Arnold, Döhner, Hartmut, Döhner, Konstanze
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; Age Factors; Aged; Antineoplastic Agents - therapeutic use; Bone Marrow - metabolism; Bone Marrow - pathology; Core Binding Factor Alpha 2 Subunit - genetics; Core Binding Factor Alpha 2 Subunit - metabolism; DNA (Cytosine-5-)-Methyltransferases - genetics; DNA (Cytosine-5-)-Methyltransferases - metabolism; Female; fms-Like Tyrosine Kinase 3 - genetics; fms-Like Tyrosine Kinase 3 - metabolism; Humans; Isocitrate Dehydrogenase - genetics; Isocitrate Dehydrogenase - metabolism; Karyotype; Leukemia, Myeloid, Acute - diagnosis; Leukemia, Myeloid, Acute - drug therapy; Leukemia, Myeloid, Acute - genetics; Leukemia, Myeloid, Acute - mortality; Male; Middle Aged; Nuclear Proteins - genetics; Nuclear Proteins - metabolism; Prognosis; Prospective Studies; Repressor Proteins - genetics; Repressor Proteins - metabolism; Sex Factors; Survival Analysis
• ISSN: 0390-6078; 1592-8721
• DOI: 10.3324/haematol.2014.114157

We studied 1696 patients (18 to 61 years) with acute myeloid leukemia for ASXL1 mutations and identified these mutations in 103 (6.1%) patients. ASXL1 mutations were associated with older age (P