PSMA as a Theranostic Target in Hepatocellular Carcinoma: Immunohistochemistry and 68Ga‐PSMA‐11 PET Using Cyclotron‐Produced 68Ga

Prostate‐specific membrane antigen (PSMA) is a validated target for molecular diagnostics and targeted radionuclide therapy. Our purpose was to evaluate PSMA expression in hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatic adenoma (HCA); investigate the genetic pathways in HCC ass...

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Published in:Hepatology communications 2022-05, Vol.6 (5), p.1172-1185
Main Authors: Thompson, Scott M., Suman, Garima, Torbenson, Michael S., Chen, Zong‐Ming E., Jondal, Danielle E., Patra, Anurima, Ehman, Eric C., Andrews, James C., Fleming, Chad J., Welch, Brian T., Kurup, Anil N., Roberts, Lewis R., Watt, Kymberly D., Truty, Mark J., Cleary, Sean P., Smoot, Rory L., Heimbach, Julie K., Tran, Nguyen H., Mahipal, Amit, Yin, Jun, Zemla, Tyler, Wang, Chen, Fogarty, Zachary, Jacobson, Mark, Kemp, Bradley J., Venkatesh, Sudhakar K., Johnson, Geoffrey B., Woodrum, David A., Goenka, Ajit H.
Format: Article
Language:English
Subjects:
Agreements
Antigens
Biopsy
Cholangiocarcinoma
FDA approval
Genes
Genomes
Hepatitis B
Hepatitis C
Immunotherapy
Liver cancer
Liver cirrhosis
Magnetic resonance imaging
Original
Peptides
Prostate cancer
Protein expression
Proteins
Radiation therapy
Tomography
Tumors
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Summary:Prostate‐specific membrane antigen (PSMA) is a validated target for molecular diagnostics and targeted radionuclide therapy. Our purpose was to evaluate PSMA expression in hepatocellular carcinoma (HCC), cholangiocarcinoma (CCA), and hepatic adenoma (HCA); investigate the genetic pathways in HCC associated with PSMA expression; and evaluate HCC detection rate with 68Ga‐PSMA‐11 positron emission tomography (PET). In phase 1, PSMA immunohistochemistry (IHC) on HCC (n = 148), CCA (n = 111), and HCA (n = 78) was scored. In a subset (n = 30), messenger RNA (mRNA) data from the Cancer Genome Atlas HCC RNA sequencing were correlated with PSMA expression. In phase 2, 68Ga‐PSMA‐11 PET was prospectively performed in patients with treatment‐naïve HCC on a digital PET scanner using cyclotron‐produced 68Ga. Uptake was graded qualitatively and semi‐quantitatively using standard metrics. On IHC, PSMA expression was significantly higher in HCC compared with CCA and HCA (P 
ISSN:2471-254X
2471-254X
DOI:10.1002/hep4.1861