Candidate genes involved in the development of antipsychotic-induced tardive dyskinesia in patients with schizophrenia

• Published in: Nervno-myshechnye bolezni 2020-12, Vol.10 (3), p.10-26
• Main Authors: Vaiman, E. E., Shnayder, N. A., Neznanov, N. G., Nasyrova, R. F.
• Format: Article
• Language: English
• Subjects: antipsychotics; drug-induced tardive dyskinesia; genes; tardive dyskinesia
• ISSN: 2222-8721; 2413-0443
• DOI: 10.17650/2222-8721-2020-10-3-10-26

Introduction. Drug-induced dyskinesia is an iatrogenic undesirable side reaction from the extrapyramidal system that occurs during the administration of drugs, most often antipsychotics in patients with schizophrenia. At the end of the 20 th century, studies were conducted on the search for candidate genes and the carriage of single nucleotide variants of antipsychotics-induced tardive dyskinesia. Purpose of the study – to analyze research results reflecting candidate genes and their single nucleotide variants associated with antipsychotic-induced tardive dyskinesia. Materials and methods. We searched for full-text publications in Russian and English in the eLIBRARY, PubMed, Web of Science, Springer databases using keywords (tardive dyskinesia, drug-induced tardive dyskinesia, antipsychotics, antipsychotics, typical antipsychotics, atypical antipsychotics, genes, polymorphisms) and combined searches for words over the past decade. Results. The lecture discusses candidate genes encoding proteins/enzymes involved in the pharmacodynamics and pharmacokinetics of antipsychotics Conclusion. Timely identification of individual genetic characteristics of the patient can contribute to the development of diagnostic test systems and in the future selection of the safest and most effective antipsychotic therapy.