Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study

ObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD. MethodsA total of 112 patients undergoing PD with drain f...

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Published in:Frontiers in oncology 2022-09, Vol.12, p.993901-993901
Main Authors: Xie, Xuehai, Chen, Kai, Liu, Zonghao, Wang, Feng, Ma, Yongsu, Zhang, Shupeng, Shao, Zhijiang, Yang, Yinmo, Tian, Xiaodong
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Language:English
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early drain removal
Oncology
pancreatic cancer
pancreaticoduodenectomy
postoperative complications
postoperative pancreatic fistula
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cited_by cdi_FETCH-LOGICAL-c439t-2c7a370b37ab1dab1f01cf3303e46bcb0acd2001dbafc93de21dddc80f3a4cf03
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container_title Frontiers in oncology
container_volume 12
creator Xie, Xuehai
Chen, Kai
Liu, Zonghao
Wang, Feng
Ma, Yongsu
Zhang, Shupeng
Shao, Zhijiang
Yang, Yinmo
Tian, Xiaodong
description ObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD. MethodsA total of 112 patients undergoing PD with drain fluid amylase (DFA) on postoperative day (POD) 1 and 3
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This single-center retrospective cohort study was designed to explore the safety of EDR after PD. MethodsA total of 112 patients undergoing PD with drain fluid amylase (DFA) on postoperative day (POD) 1 and 3 &lt;= 5000 were divided into EDR and late drain removal (LDR). Propensity Score Matching (PSM) was used. We compared postoperative outcomes between two groups and explore the risk factors of total complications using univariate and multiple logistic regression analyses. ResultsNo statistical differences were found in primary outcomes, including Grade B/C postoperative pancreatic fistula (POPF) (Original cohort: 5.71% vs. 3.90%; P = 1.000; PSM cohort: 3.33% vs. 6.67%; P = 1.000), and total complications (Original cohort: 17.14% vs. 32.47%; P = 0.093; PSM cohort: 13.33% vs. 33.33%; P = 0.067). The EDR was associated with shorter in-hospital stay (Original cohort: 11 days vs. 15 days; P &lt; 0.0001; PSM cohort: 11 days vs. 15 days; P &lt; 0.0001). ConclusionsEDR on POD 3 is safe for patients undergoing PD with low risk of POPF.</description><identifier>ISSN: 2234-943X</identifier><identifier>EISSN: 2234-943X</identifier><identifier>DOI: 10.3389/fonc.2022.993901</identifier><language>eng</language><publisher>Frontiers Media S.A</publisher><subject>early drain removal ; Oncology ; pancreatic cancer ; pancreaticoduodenectomy ; postoperative complications ; postoperative pancreatic fistula</subject><ispartof>Frontiers in oncology, 2022-09, Vol.12, p.993901-993901</ispartof><rights>Copyright © 2022 Xie, Chen, Liu, Wang, Ma, Zhang, Shao, Yang and Tian 2022 Xie, Chen, Liu, Wang, Ma, Zhang, Shao, Yang and Tian</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c439t-2c7a370b37ab1dab1f01cf3303e46bcb0acd2001dbafc93de21dddc80f3a4cf03</citedby><cites>FETCH-LOGICAL-c439t-2c7a370b37ab1dab1f01cf3303e46bcb0acd2001dbafc93de21dddc80f3a4cf03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554647/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9554647/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Xie, Xuehai</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><creatorcontrib>Liu, Zonghao</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Ma, Yongsu</creatorcontrib><creatorcontrib>Zhang, Shupeng</creatorcontrib><creatorcontrib>Shao, Zhijiang</creatorcontrib><creatorcontrib>Yang, Yinmo</creatorcontrib><creatorcontrib>Tian, Xiaodong</creatorcontrib><title>Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study</title><title>Frontiers in oncology</title><description>ObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD. MethodsA total of 112 patients undergoing PD with drain fluid amylase (DFA) on postoperative day (POD) 1 and 3 &lt;= 5000 were divided into EDR and late drain removal (LDR). Propensity Score Matching (PSM) was used. We compared postoperative outcomes between two groups and explore the risk factors of total complications using univariate and multiple logistic regression analyses. ResultsNo statistical differences were found in primary outcomes, including Grade B/C postoperative pancreatic fistula (POPF) (Original cohort: 5.71% vs. 3.90%; P = 1.000; PSM cohort: 3.33% vs. 6.67%; P = 1.000), and total complications (Original cohort: 17.14% vs. 32.47%; P = 0.093; PSM cohort: 13.33% vs. 33.33%; P = 0.067). The EDR was associated with shorter in-hospital stay (Original cohort: 11 days vs. 15 days; P &lt; 0.0001; PSM cohort: 11 days vs. 15 days; P &lt; 0.0001). ConclusionsEDR on POD 3 is safe for patients undergoing PD with low risk of POPF.</description><subject>early drain removal</subject><subject>Oncology</subject><subject>pancreatic cancer</subject><subject>pancreaticoduodenectomy</subject><subject>postoperative complications</subject><subject>postoperative pancreatic fistula</subject><issn>2234-943X</issn><issn>2234-943X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNpVkcFvFSEQxjdGE5vau0eOXvYJDLv78GDSNFqbNPGgJt4IC8PrNiw8gX1m_3tZX2PsJATCN_ODma9p3jK6A9jL9y4Gs-OU852UICl70VxwDqKVAn6-_O_8urnK-ZHW6DvKKFw0p2_aYVkJnrRfdJliINER1MmvxCY9BZJwjlUkLnoff0_hQI46mIQ12US7RIsBTYnz-oFck1x1j63BUDDV0pJiPlZ5OiEx8SGmQnJZ7PqmeeW0z3j1tF82Pz5_-n7zpb3_ent3c33fGgGytNwMGgY6wqBHZutylBkHQAFFP5qRamM5pcyO2hkJFjmz1po9daCFcRQum7sz10b9qI5pmnVaVdST-nsR00HpVBvxqEbRDSD3SHtrBUC_N30dGWWcAZMcRWV9PLOOyzij3XpM2j-DPlfC9KAO8aRk14leDBXw7gmQ4q8Fc1HzlA16rwPGJSs-8E7UkNu_6TnV1AHmhO7fM4yqzXK1Wa42y9XZcvgD1a6kaA</recordid><startdate>20220929</startdate><enddate>20220929</enddate><creator>Xie, Xuehai</creator><creator>Chen, Kai</creator><creator>Liu, Zonghao</creator><creator>Wang, Feng</creator><creator>Ma, Yongsu</creator><creator>Zhang, Shupeng</creator><creator>Shao, Zhijiang</creator><creator>Yang, Yinmo</creator><creator>Tian, Xiaodong</creator><general>Frontiers Media S.A</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20220929</creationdate><title>Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study</title><author>Xie, Xuehai ; Chen, Kai ; Liu, Zonghao ; Wang, Feng ; Ma, Yongsu ; Zhang, Shupeng ; Shao, Zhijiang ; Yang, Yinmo ; Tian, Xiaodong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c439t-2c7a370b37ab1dab1f01cf3303e46bcb0acd2001dbafc93de21dddc80f3a4cf03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>early drain removal</topic><topic>Oncology</topic><topic>pancreatic cancer</topic><topic>pancreaticoduodenectomy</topic><topic>postoperative complications</topic><topic>postoperative pancreatic fistula</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Xuehai</creatorcontrib><creatorcontrib>Chen, Kai</creatorcontrib><creatorcontrib>Liu, Zonghao</creatorcontrib><creatorcontrib>Wang, Feng</creatorcontrib><creatorcontrib>Ma, Yongsu</creatorcontrib><creatorcontrib>Zhang, Shupeng</creatorcontrib><creatorcontrib>Shao, Zhijiang</creatorcontrib><creatorcontrib>Yang, Yinmo</creatorcontrib><creatorcontrib>Tian, Xiaodong</creatorcontrib><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Frontiers in oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Xuehai</au><au>Chen, Kai</au><au>Liu, Zonghao</au><au>Wang, Feng</au><au>Ma, Yongsu</au><au>Zhang, Shupeng</au><au>Shao, Zhijiang</au><au>Yang, Yinmo</au><au>Tian, Xiaodong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study</atitle><jtitle>Frontiers in oncology</jtitle><date>2022-09-29</date><risdate>2022</risdate><volume>12</volume><spage>993901</spage><epage>993901</epage><pages>993901-993901</pages><issn>2234-943X</issn><eissn>2234-943X</eissn><abstract>ObjectivesThe effects of early drain removal (EDR) on postoperative complications after pancreaticoduodenectomy (PD) remains to be investigated. This single-center retrospective cohort study was designed to explore the safety of EDR after PD. MethodsA total of 112 patients undergoing PD with drain fluid amylase (DFA) on postoperative day (POD) 1 and 3 &lt;= 5000 were divided into EDR and late drain removal (LDR). Propensity Score Matching (PSM) was used. We compared postoperative outcomes between two groups and explore the risk factors of total complications using univariate and multiple logistic regression analyses. ResultsNo statistical differences were found in primary outcomes, including Grade B/C postoperative pancreatic fistula (POPF) (Original cohort: 5.71% vs. 3.90%; P = 1.000; PSM cohort: 3.33% vs. 6.67%; P = 1.000), and total complications (Original cohort: 17.14% vs. 32.47%; P = 0.093; PSM cohort: 13.33% vs. 33.33%; P = 0.067). The EDR was associated with shorter in-hospital stay (Original cohort: 11 days vs. 15 days; P &lt; 0.0001; PSM cohort: 11 days vs. 15 days; P &lt; 0.0001). ConclusionsEDR on POD 3 is safe for patients undergoing PD with low risk of POPF.</abstract><pub>Frontiers Media S.A</pub><doi>10.3389/fonc.2022.993901</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record>
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subjects early drain removal
Oncology
pancreatic cancer
pancreaticoduodenectomy
postoperative complications
postoperative pancreatic fistula
title Safety evaluation of early drain removal following pancreaticoduodenectomy: A single-center retrospective cohort study
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