Evaluation of Immunological Parameters in Pregnant Women: Low Levels of B and NK Cells

• Published in: Revista Brasileira de ginecologia e obstetrícia 2019-04, Vol.41 (4), p.213-219
• Main Authors: de Carvalho Schettini, Juliana Araújo, Gomes, Thomás Virgílio, Júnior, Claudeir Dias da Silva, Heráclio, Sandra de Andrade, Coelho, Isabela Cristina Coutinho de Albuquerque Neiva, Torres, Leuridan Cavalcante
• Format: Article
• Language: English
• Subjects: Adolescent; Adult; B-lymphocytes; Cross-Sectional Studies; Databases, Factual; Female; Humans; immunophenotyping; Killer Cells, Natural - physiology; NK cell; OBSTETRICS & GYNECOLOGY; Original; pregnancy; Pregnancy - blood; Pregnancy - immunology; Pregnancy Trimesters; reference range; Reference Values; Retrospective Studies; T-Lymphocytes; T-Lymphocytes - physiology; Young Adult
• ISSN: 0100-7203; 1806-9339; 1806-9339
• DOI: 10.1055/s-0039-1683903

To describe the immunological and hematological reference intervals of low-risk pregnant women.  A cross-sectional retrospective database analysis of a basic and translational study analyzing the hematological evaluation blood counts and immunophenotyping of TCD3 + , TCD4 + , TCD8 + , B, and natural killer (NK) cells of the peripheral blood in 79 low-risk pregnant women and of 30 control women from the state of Pernambuco, Brazil, was performed.  No significant differences were detected between the hematological profiles of the 2 and 3 trimesters. Nevertheless, the median level of B cells decreased significantly in the 2 (174 × 10 µL;