Retinal phototoxicity after macular hole surgery in a patient under paclitaxel

The purpose is to report the second case, to our knowledge, of suspected paclitaxel-induced phototoxic maculopathy following pars plana vitrectomy surgery. 63-year-old phakic female who underwent an uneventful phaco-vitrectomy to treat a complete macular hole, developing macular phototoxicity in the...

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Bibliographic Details
Published in:BMC ophthalmology 2023-08, Vol.23 (1), p.342-342, Article 342
Main Authors: Ruiz-Moreno, José M, García-Zamora, María, Ruiz-Medrano, Jorge
Format: Article
Language:English
Subjects:
Breast cancer
Cancer
Case Report
Case reports
Cataracts
Chemotherapy
Edema
Female
Glaucoma
Humans
Macular phototoxicity
Middle Aged
Ophthalmology
Paclitaxel
Paclitaxel - adverse effects
Pertuzumab
Pharmacists
Photosensitivity
Photosensitization
Phototoxicity
Retina
Retinal Diseases - surgery
Retinal Perforations - diagnosis
Retinal Perforations - surgery
Retrospective Studies
Surgery
Tomography, Optical Coherence
Toxicity
Visual acuity
Vitrectomy
Vitrectomy - adverse effects
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Summary:The purpose is to report the second case, to our knowledge, of suspected paclitaxel-induced phototoxic maculopathy following pars plana vitrectomy surgery. 63-year-old phakic female who underwent an uneventful phaco-vitrectomy to treat a complete macular hole, developing macular phototoxicity in the post-operatively period that could not be explained by the surgery itself and could only be attributed to a possible photosensitization induced by the previous use of paclitaxel. The use of paclitaxel has been widely extended as a chemotherapy drug to treat breast cancer. It works by altering the intracellular microtubular reorganization and, based on this mechanism of action, photosensitivity has been previously described. We report a case of suspected paclitaxel-induced macular phototoxicity following ocular endoillumination during vitrectomy surgery.
ISSN:1471-2415
1471-2415
DOI:10.1186/s12886-023-03086-x