The isolation, bioactivity, and synthesis of natural products from Litsea verticillate with anti-HIV activities

Natural products isolated from have attracted considerable attention from the chemical community due to their unique structures and promising anti-HIV activities. Recent progresses in the isolation and bioactivity studies for these natural molecules were summarized comprehensively. From the 23 previ...

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Bibliographic Details
Published in:Frontiers in pharmacology 2024-12, Vol.15, p.1477878
Main Authors: Yan, Jia-Lei, Nan, Huiru, Fang, Xiaoyu, Long, Xiong-En, Jiang, Yu, Liu, Junyang
Format: Article
Language:English
Subjects:
anti-HIV
bioactive
litsea verticillate
natural product
Pharmacology
total synthesis
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Summary:Natural products isolated from have attracted considerable attention from the chemical community due to their unique structures and promising anti-HIV activities. Recent progresses in the isolation and bioactivity studies for these natural molecules were summarized comprehensively. From the 23 previously uncharacterized compounds isolated from the plant , litseaverticillol B demonstrated the most potent anti-HIV activity , with IC ranging from 2 to 3 μg/mL. Meanwhile, litseaverticillol E displayed the highest selectivity index (SI = 3.1), indicating a favorable balance between antiviral potency and cellular toxicity. The plausible biosynthetic pathways and the total synthetic approaches for the representative members (litseaverticillols) were introduced in detail.
ISSN:1663-9812
1663-9812
DOI:10.3389/fphar.2024.1477878