A case of topical rapamycin effective for postsurgical hypertrophic scar of superficial lymphatic malformation with possible quality-of-life improvement

Lymphatic malformation (LM) of the body surface causes symptoms such as bleeding, pain, lymphatic leakage, or infection of the lesion, usually treated with surgical resection and sclerotherapy, with limited efficacy. The vesicles of the body surface tend to recur after surgical resection and may cau...

Full description

Saved in:
Bibliographic Details
Published in:Journal of dermatology & dermatologic surgery 2022-08, Vol.26 (3), p.11-14
Main Authors: Isozaki, Yuki, Kato, Motoi, Fujita, Naoko, Tojo, Shota, Fujiki, Masahide, Watanabe, Azusa, Watanabe, Shoji
Format: Article
Language:English
Subjects:
lymphatic malformation
quality of life
rapamycin
scar/keloid
therapy (topical)
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Lymphatic malformation (LM) of the body surface causes symptoms such as bleeding, pain, lymphatic leakage, or infection of the lesion, usually treated with surgical resection and sclerotherapy, with limited efficacy. The vesicles of the body surface tend to recur after surgical resection and may cause lymphatic leakage, which could be long term a burden for patients, eventually decreasing their quality of life. In recent years, the efficacy of orally administered mammalian target of rapamycin inhibitor (rapamycin) has been reported for LM and other vascular anomalies but few are reported in the East Asian population. We report the case of a Japanese female with intractable gluteal LM that was successfully treated with topical rapamycin for postoperative recurrence and hypertrophic scarring.
ISSN:2352-2410
2352-2429
DOI:10.4103/jdds.jdds_38_21