Novel BRD2::NUTM1 Fusion in NUT Carcinoma With Exceptional Response to Chemotherapy: A Case Report

We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura. Eventually, a positive NUT immunohistochemistry, NUT fluorescence in situ hybridization, and RNA next-gener...

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Bibliographic Details
Published in:JTO clinical and research reports 2024-01, Vol.5 (1), p.100625, Article 100625
Main Authors: Wu, Sarah J., Kim, Justin J., Huang, Yeying, Durall, R. Taylor, Becker, Simone, Canty, Stephanie, Molinaro, Stefania, Pisick, Evan, Shapiro, Geoffrey I., French, Christopher A., Luo, Jia
Format: Article
Language:English
Subjects:
BRD2::NUTM1 gene fusion
Case Report
Non–small cell lung cancer
NUT carcinoma
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Summary:We present the first known case of a patient with BRD2::NUTM1-driven NUT carcinoma. A 59-year-old woman presented with poorly differentiated squamous cell lung cancer metastatic to the pleura. Eventually, a positive NUT immunohistochemistry, NUT fluorescence in situ hybridization, and RNA next-generation sequencing with a BRD2::NUTM1 fusion led to the diagnosis of NUT carcinoma. She received multiple lines of chemotherapy with response and is still alive at 2 years postdiagnosis. This report expands on the known fusions in NUT carcinoma and highlights potential differences in patient prognosis on the basis of gene fusion partners.
ISSN:2666-3643
2666-3643
DOI:10.1016/j.jtocrr.2023.100625