Anti-inflammatory and anti-oxidant activities of Mallotus oppositifolius (Geisel) methanol leaf extracts

The methanol leaf extract of Mallotus oppositifolius was evaluated for anti-inflammatory activity in rats and mice using acute and chronic anti-inflammatory models with acetylsalicylate acid (aspirin) as the reference drug. The antioxidant activity was done in vitro using ferric reducing antioxidant...

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Bibliographic Details
Published in:Arabian journal of chemistry 2014-11, Vol.7 (5), p.805-810
Main Authors: Nwaehujor, Chinaka O., Ezeja, Maxwell I., Udeh, Nkeiruka E., Okoye, Dozie N., Udegbunam, Rita I.
Format: Article
Language:English
Subjects:
Acetylsalicylate acid
Carrageenan
DPPH
Edema
FRAP
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Summary:The methanol leaf extract of Mallotus oppositifolius was evaluated for anti-inflammatory activity in rats and mice using acute and chronic anti-inflammatory models with acetylsalicylate acid (aspirin) as the reference drug. The antioxidant activity was done in vitro using ferric reducing antioxidant power (FRAP) and 1,1-diphenyl-2-hydrazyl (DPPH) spectrophotometric assays. The extract dose dependently and significantly reduced paw edema volume in rats induced by carrageenan (p
ISSN:1878-5352
1878-5379
DOI:10.1016/j.arabjc.2012.03.014