Colonic Cancer and Acromegaly

Acromegaly results in a significantly increased morbidity and mortality due to cardiovascular and respiratory complications, as well as malignancies arising mainly from the colon. Furthermore, an increased lifetime risk of malignant transformation of pre-malignant colonic lesions relates to a worse...

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Bibliographic Details
Published in:Frontiers in endocrinology (Lausanne) 2019-06, Vol.10, p.390-390
Main Authors: Dworakowska, Dorota, Grossman, Ashley B
Format: Article
Language:English
Subjects:
acromegaly
cancer
colon
colonoscopy
Endocrinology
screening
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Summary:Acromegaly results in a significantly increased morbidity and mortality due to cardiovascular and respiratory complications, as well as malignancies arising mainly from the colon. Furthermore, an increased lifetime risk of malignant transformation of pre-malignant colonic lesions relates to a worse overall prognosis from colorectal cancer, which is currently considered a major disease-related complication. In this review we provide some insight into colonic changes in this condition, summarize current knowledge and evidence on the use of colonoscopic screening in patients with acromegaly, and suggest a recommended screening protocol.
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2019.00390