Norovirus gastroenteritis outbreak with a secretor-independent susceptibility pattern, Sweden

Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroent...

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Bibliographic Details
Published in:Emerging infectious diseases 2010-01, Vol.16 (1), p.81-87
Main Authors: Nordgren, Johan, Kindberg, Elin, Lindgren, Per Eric, Matussek, Andreas, Svensson, Lennart
Format: Article
Language:English
Subjects:
ABO Blood-Group System
Adult
Antigens
Base Sequence
Caliciviridae Infections - blood
Caliciviridae Infections - epidemiology
Caliciviridae Infections - virology
Development and progression
Disease Outbreaks
Disease susceptibility
enteric infections
Gastroenteritis
Gastroenteritis - blood
Gastroenteritis - epidemiology
Gastroenteritis - virology
Genetic aspects
Genetic Predisposition to Disease
GI.3
histo-blood group antigens
Humans
Lewis Blood-Group System
MEDICIN
MEDICINE
Molecular Sequence Data
Norovirus
Norovirus - genetics
Odds Ratio
Phenotype
Polymerase Chain Reaction
Saliva - virology
Sequence Homology, Amino Acid
susceptibility
Sweden - epidemiology
Virus Shedding - genetics
viruses
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Description
Summary:Norovirus (NoV) is recognized as the commonest cause of acute gastroenteritis among adults. Susceptibility to disease has been associated with histo-blood group antigens and secretor status; nonsecretors are almost completely resistant to disease. We report a foodborne outbreak of GI.3 NoV gastroenteritis that affected 33/83 (40%) persons. Symptomatic disease was as likely to develop in nonsecretors as in secretors (odds ratio [OR] 1.41, 95% confidence interval [CI] 0.46-4.36 vs. OR 0.71, 95% CI 0.23-2.18, p = 0.57). Moreover, no statistical difference in susceptibility was found between persons of different Lewis or ABO phenotypes. The capsid gene of the outbreak strain shares high amino acid homology with the Kashiwa645 GI.3 strain, previously shown to recognize nonsecretor saliva, as well as synthetic Lewis a. This norovirus outbreak affected persons regardless of secretor status or Lewis or ABO phenotypes.
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1601.090633