Effect of methylprednisolone use on the rotator cuff in rats: biomechanical and histological study

To evaluate the influence of treatment with different doses of methylprednisolone on the mechanical resistance and possible histological alterations of the rotator cuff tendon in rats. Male Wistar rats were divided randomly into four treatment groups: sham, vehicle or 0.6mg/kg or 6.0mg/kg of methylp...

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Bibliographic Details
Published in:Revista brasileira de ortopedia 2015-05, Vol.50 (3), p.260-265
Main Authors: Ghellioni, Gustavo Vinícius, da Silva, Lucas Souto, Piovezan, Anna Paula, Martins, Rafael Olívio
Format: Article
Language:English
Subjects:
Corticoides
Corticoids
Manguito rotador
Original
ORTHOPEDICS
Ortopedia
Rotator cuff
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Summary:To evaluate the influence of treatment with different doses of methylprednisolone on the mechanical resistance and possible histological alterations of the rotator cuff tendon in rats. Male Wistar rats were divided randomly into four treatment groups: sham, vehicle or 0.6mg/kg or 6.0mg/kg of methylprednisolone. Changes to mechanical resistance (in N) and histological parameters (fibrillar appearance, presence of collagen, edema and vascular proliferation) of the rotator cuff tendon were evaluated. The analyses were conducted after administration of one treatment (24h afterwards), two treatments (7 days afterward) or three treatments (14 days afterwards), into the subacromial space. Seven and fourteen days after the treatments were started, it was found that in a dose-dependent manner, methylprednisolone reduced the mechanical resistance of the rotator cuff tendon (p
ISSN:2255-4971
1982-4378
2255-4971
DOI:10.1016/j.rboe.2015.05.002